Sharman, JE and Stanton, T and Reid, CM and Keech, A and Roberts-Thomson, P and Stewart, S and Greenough, R and Stowasser, M and Abhayaratna, WP, Targeted LOWering of central blood pressure in patients with hypertension: baseline recruitment, rationale and design of a randomized controlled trial (The LOW CBP study), Contemporary Clinical Trials, 62 pp. 37-42. ISSN 1551-7144 (2017) [Refereed Article]
© 2017 Elsevier
Methods: This is a multi-centre, randomized, open-label, blinded endpoint trial among 308 patients treated for uncomplicated hypertension with controlled brachial BP (< 140/90 mm Hg) but elevated central BP (≥ 0.5SD above age- and sex-specific normal values). Baseline recruitment has been completed. Participants were randomized to intervention with spironolactone (25 mg/d) or usual care and are being followed over 24 months, with the primary outcome being left ventricular mass index (using cardiac magnetic resonance imaging). Brachial and central BP will be measured in the clinic, at home over 7-days and by 24-hour ambulatory monitoring. Aortic stiffness will be assessed by carotid-to-femoral pulse wave velocity. Primary (intention to treat) analysis will determine the role of central versus brachial BP for predicting changes in left ventricular mass index.
Conclusions: Compared with control, intervention is expected to significantly lower left ventricular mass index, and this effect is expected to be independently correlated with central BP lowering. These findings would support the concept of central BP as an important therapeutic target in hypertension management. Results are expected in 2018.
|Item Type:||Refereed Article|
|Keywords:||arteries, ascending aorta, myocardial, hypertension, therapy|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Sharman, JE (Professor James Sharman)|
|Author:||Roberts-Thomson, P (Dr Philip Roberts-Thomson)|
|Deposited By:||Menzies Institute for Medical Research|
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