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Maintaining vitamin D sufficiency is associated with improved structural and symptomatic outcomes in knee osteoarthritis


Zheng, S and Jin, X and Cicuttini, F and Wang, X and Zhu, Z and Wluka, A and Han, W and Winzenberg, T and Antony, B and Aitken, D and Blizzard, L and Jones, G and Ding, C, Maintaining vitamin D sufficiency is associated with improved structural and symptomatic outcomes in knee osteoarthritis, American Journal of Medicine, 130, (10) pp. 1211-1218. ISSN 0002-9343 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 Elsevier Inc.

DOI: doi:10.1016/j.amjmed.2017.04.038


Background: The aim of this study was to describe whether maintaining sufficient serum vitamin D levels in people with knee osteoarthritis and baseline vitamin D insufficiency has an association with change in knee structures and symptoms over 2 years.

Methods: Participants (n = 413, mean age 63.2 years) with symptomatic knee osteoarthritis and vitamin D insufficiency were enrolled in a clinical trial. In all, 340 participants (82.3%) completed the study, with 25-hydroxyvitamin D [25(OH)D] measurements at baseline and months 3 and 24. Participants were classified as consistently insufficient [serum 25(OH)D ≤ 50 nmol/L at months 3 and 24, n = 45], fluctuating [25(OH)D > 50 nmol/L at either point, n = 68), and consistently sufficient [25(OH)D > 50 nmol/L at months 3 and 24, n = 226] groups. Knee cartilage volume, cartilage defects, bone marrow lesions, and effusion-synovitis volume were assessed using MRI at baseline and month 24. Knee symptoms were assessed at baseline and months 3, 6, 12, and 24 using the Western Ontario and McMaster Universities Arthritis Index.

Results: The consistently sufficient group had significantly less loss of tibial cartilage volume (β 2.1%; 95% confidence interval [CI], 0.3%, 3.9%), less increase in effusion-synovitis volume (β -2.5 mL; 95 CI%, -4.7, -0.2 mL), and less loss of Western Ontario and McMaster Universities Arthritis Index physical function (β -94.2; 95% CI, -183.8, -4.5) compared with the consistently insufficient group in multivariable analyses. In contrast, there were no significant differences in these outcomes between the fluctuating and consistently insufficient groups. Changes in cartilage defects, bone marrow lesions, and knee pain were similar between groups.

Conclusion: This post hoc analysis suggests beneficial effects of maintaining vitamin D sufficiency on cartilage loss, effusion-synovitis, and physical function in people with knee osteoarthritis.

Item Details

Item Type:Refereed Article
Keywords:knee osteoarthritis, MRI, post hoc, vitamin D
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zheng, S (Miss Shuang Zheng)
UTAS Author:Jin, X (Mr Xingzhong Jin)
UTAS Author:Wang, X (Ms Xia Wang)
UTAS Author:Zhu, Z (Mr Zhaohua Zhu)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:120306
Year Published:2017
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-21
Last Modified:2018-06-20

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