Zheng, S and Jin, X and Cicuttini, F and Wang, X and Zhu, Z and Wluka, A and Han, W and Winzenberg, T and Antony, B and Aitken, D and Blizzard, L and Jones, G and Ding, C, Maintaining vitamin D sufficiency is associated with improved structural and symptomatic outcomes in knee osteoarthritis, American Journal of Medicine, 130, (10) pp. 1211-1218. ISSN 0002-9343 (2017) [Refereed Article]
Copyright 2017 Elsevier Inc.
Methods: Participants (n = 413, mean age 63.2 years) with symptomatic knee osteoarthritis and vitamin D insufficiency were enrolled in a clinical trial. In all, 340 participants (82.3%) completed the study, with 25-hydroxyvitamin D [25(OH)D] measurements at baseline and months 3 and 24. Participants were classified as consistently insufficient [serum 25(OH)D ≤ 50 nmol/L at months 3 and 24, n = 45], fluctuating [25(OH)D > 50 nmol/L at either point, n = 68), and consistently sufficient [25(OH)D > 50 nmol/L at months 3 and 24, n = 226] groups. Knee cartilage volume, cartilage defects, bone marrow lesions, and effusion-synovitis volume were assessed using MRI at baseline and month 24. Knee symptoms were assessed at baseline and months 3, 6, 12, and 24 using the Western Ontario and McMaster Universities Arthritis Index.
Results: The consistently sufficient group had significantly less loss of tibial cartilage volume (β 2.1%; 95% confidence interval [CI], 0.3%, 3.9%), less increase in effusion-synovitis volume (β -2.5 mL; 95 CI%, -4.7, -0.2 mL), and less loss of Western Ontario and McMaster Universities Arthritis Index physical function (β -94.2; 95% CI, -183.8, -4.5) compared with the consistently insufficient group in multivariable analyses. In contrast, there were no significant differences in these outcomes between the fluctuating and consistently insufficient groups. Changes in cartilage defects, bone marrow lesions, and knee pain were similar between groups.
Conclusion: This post hoc analysis suggests beneficial effects of maintaining vitamin D sufficiency on cartilage loss, effusion-synovitis, and physical function in people with knee osteoarthritis.
|Item Type:||Refereed Article|
|Keywords:||knee osteoarthritis, MRI, post hoc, vitamin D|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Zheng, S (Miss Shuang Zheng)|
|Author:||Jin, X (Mr Xingzhong Jin)|
|Author:||Wang, X (Ms Xia Wang)|
|Author:||Zhu, Z (Mr Zhao Zhu)|
|Author:||Han, W (Dr Weiyu Han)|
|Author:||Winzenberg, T (Professor Tania Winzenberg)|
|Author:||Antony, B (Mr Benny Eathakkattu Antony)|
|Author:||Aitken, D (Dr Dawn Aitken)|
|Author:||Blizzard, L (Professor Leigh Blizzard)|
|Author:||Jones, G (Professor Graeme Jones)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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