University of Tasmania
Browse

File(s) under permanent embargo

Pain and antisepsis after ocular administration of povidone-iodine versus chlorhexidine

journal contribution
posted on 2023-05-19, 09:59 authored by Oakley, C, Allen, P, Hooshmand, J, Vote, BJT

Purpose:

To investigate ocular bacterial count before and after antisepsis with aqueous chlorhexidine (AC) or povidone-iodine (PI) and to assess discomfort with each agent.

Methods:

Bacterial swabs were taken from participants’ eyes before and after antisepsis. These underwent microscopy, culture, and sensitivity testing. Aqueous chlorhexidine drops were administered to left eyes and PI to right eyes. Participants rated their pain (scale 0–10) for each eye but were blinded to the type of drop.

Results:

There were 20 participants (17 women, 3 men), and the mean age was 43 years. Pain scores were significantly higher in right (PI) than in left (AC) eyes (mean 7 vs. mean 2, P > 0.001). No abnormalities were detected on specimen microscopy and gram staining. Seven preantisepsis swabs (three left and four right) grew bacteria in culture. Two postantisepsis swabs grew bacteria in primary culture plate (1 after AC and 1 after PI). For an additional one post-PI swab, bacteria were detected in enrichment broth only.

Conclusion:

The efficacy of AC and PI are similar, and patient discomfort is lower with AC. Aqueous chlorhexidine is a good alternative to PI for antisepsis before intravitreal injection.

History

Publication title

Retina: The Journal of Retinal and Vitreous Diseases

Volume

38

Issue

10

Pagination

2064-2066

ISSN

0275-004X

Department/School

Tasmanian School of Medicine

Publisher

Lippincott Williams & Wilkins

Place of publication

USA

Rights statement

Copyright 2017 Ophthalmic Communications Society, Inc.

Repository Status

  • Restricted

Socio-economic Objectives

Treatment of human diseases and conditions

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC