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Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis

journal contribution
posted on 2023-05-19, 09:59 authored by Zhu, Q, Xu, J, Wang, K, Cai, J, Wu, J, Ren, J, Zheng, S, Chang-Hai DingChang-Hai Ding
Aim: The relationship between bone mineral density (BMD) and osteoarthritis (OA) remains controversial. This study aimed to explore the cross-sectional associations between BMD at the total body, hip and spine and joint structural abnormalities including cartilage defects and bone marrow lesions (BMLs) in patients with knee OA.

Method: One hundred and eight-five subjects with symptomatic knee OA were included in this study. T2-weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BMLs. Total body, hip and spine BMD were measured using dual-energy X-ray absorptiometry.

Results: After adjustment for potential confounders, total hip BMD was negatively associated with medial tibial cartilage defects, lateral femoral cartilage defects, medial tibial BMLs and lateral tibial BMLs. Spine and total body BMD were negatively associated with lateral femoral cartilage defects, but not with BMLs.

Conclusion: We concluded that BMD particularly at the hip was negatively associated with knee cartilage defects and BMLs.

History

Publication title

International Journal of Rheumatic Diseases

Volume

21

Issue

6

Pagination

1202-1210

ISSN

1756-1841

Department/School

Menzies Institute for Medical Research

Publisher

Wiley-Blackwell Publishing Asia

Place of publication

Australia

Rights statement

© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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