Zhu, Q and Xu, J and Wang, K and Cai, J and Wu, J and Ren, J and Zheng, S and Ding, C, Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis, International Journal of Rheumatic Diseases pp. 1-9. ISSN 1756-1841 (2017) [Refereed Article]
METHOD: One hundred and eight-five subjects with symptomatic knee OA were included in this study. T2-weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BMLs. Total body, hip and spine BMD were measured using dual-energy X-ray absorptiometry.
RESULTS: After adjustment for potential confounders, total hip BMD was negatively associated with medial tibial cartilage defects, lateral femoral cartilage defects, medial tibial BMLs and lateral tibial BMLs. Spine and total body BMD were negatively associated with lateral femoral cartilage defects, but not with BMLs.
CONCLUSION: We concluded that BMD particularly at the hip was negatively associated with knee cartilage defects and BMLs.
|Item Type:||Refereed Article|
|Keywords:||osteoarthritis, bone mineral density, knee, magnetic resonance imaging|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Zheng, S (Miss Shuang Zheng)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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