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Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis

Citation

Zhu, Q and Xu, J and Wang, K and Cai, J and Wu, J and Ren, J and Zheng, S and Ding, C, Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis, International Journal of Rheumatic Diseases pp. 1-9. ISSN 1756-1841 (2017) [Refereed Article]


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DOI: doi:10.1111/1756-185X.13148

Abstract

AIM: The relationship between bone mineral density (BMD) and osteoarthritis (OA) remains controversial. This study aimed to explore the cross-sectional associations between BMD at the total body, hip and spine and joint structural abnormalities including cartilage defects and bone marrow lesions (BMLs) in patients with knee OA.

METHOD: One hundred and eight-five subjects with symptomatic knee OA were included in this study. T2-weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BMLs. Total body, hip and spine BMD were measured using dual-energy X-ray absorptiometry.

RESULTS: After adjustment for potential confounders, total hip BMD was negatively associated with medial tibial cartilage defects, lateral femoral cartilage defects, medial tibial BMLs and lateral tibial BMLs. Spine and total body BMD were negatively associated with lateral femoral cartilage defects, but not with BMLs.

CONCLUSION: We concluded that BMD particularly at the hip was negatively associated with knee cartilage defects and BMLs.

Item Details

Item Type:Refereed Article
Keywords:osteoarthritis, bone mineral density, knee, magnetic resonance imaging
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Zheng, S (Miss Shuang Zheng)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:120269
Year Published:2017
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-17
Last Modified:2017-08-22
Downloads:0

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