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Early life factors, obesity risk, and the metabolome of young adults


Rauschert, S and Mori, TA and Beilin, LJ and Jacoby, P and Uhl, O and Koletzko, B and Oddy, WH and Hellmuth, C, Early life factors, obesity risk, and the metabolome of young adults, Obesity, 25, (9) pp. 1549-1555. ISSN 1930-7381 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 The Obesity Society

DOI: doi:10.1002/oby.21915


Objective: Noncommunicable diseases such as obesity have become a serious global public health epidemic. This study aimed to examine whether there was an association between early life factors (with a special focus on breastfeeding) BMI, waist circumference, and the metabolome in offspring at 20 years.

Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study were analyzed using 1,024 plasma samples from the 20-year follow-up. A liquid chromatography, tandem mass spectrometry metabolomics approach was used to measure metabolites. Multiple linear regression models were performed and adjusted for relevant confounders. Inverse probability weighting was used to adjust the 20-year data for differences in socioeconomic variables between participants and nonparticipants since the commencement of the study.

Results: An inverse association between breastfeeding and BMI or waist circumference at 20 years was lost after adjusting for parental prepregnancy BMI and maternal smoking during pregnancy. There was no significant effect of breastfeeding on metabolite concentrations at 20 years.

Conclusions: Although other studies have shown associations between breastfeeding, obesity, and metabolite concentrations at younger ages, this was not evident in our study in young adults. We found no association of metabolites previously associated with waist circumference at 20 years and breastfeeding in early life.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutrition and dietetics not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:120239
Year Published:2017
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-17
Last Modified:2022-08-24

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