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How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?
Citation
Gasperini, RJ and Pavez, M and Thompson, AC and Mitchell, Camila and Hardy, H and Young, KM and Chilton, JK and Foa, L, How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?, Molecular and Cellular Neurosciences ISSN 1044-7431 (In Press) [Refereed Article]
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DOI: doi:10.1016/j.mcn.2017.07.006
Abstract
The precision with which neurons form connections is crucial for the normal development and function of the
nervous system. The development of neuronal circuitry in the nervous system is accomplished by axon pathfinding:
a process where growth cones guide axons through the embryonic environment to connect with their
appropriate synaptic partners to form functional circuits. Despite intense efforts over many years to understand
how this process is regulated, the complete repertoire of molecular mechanisms that govern the growth cone
cytoskeleton and hence motility, remain unresolved. A central tenet in the axon guidance field is that calcium
signals regulate growth cone behaviours such as extension, turning and pausing by regulating rearrangements of
the growth cone cytoskeleton. Here, we provide evidence that not only the amplitude of a calcium signal is
critical for growth cone motility but also the source of calcium mobilisation. We provide an example of this idea
by demonstrating that manipulation of calcium signalling via L-type voltage gated calcium channels can perturb
sensory neuron motility towards a source of netrin-1. Understanding how calcium signals can be transduced to
initiate cytoskeletal changes represents a significant gap in our current knowledge of the mechanisms that
govern axon guidance, and consequently the formation of functional neural circuits in the developing nervous
system.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | Growth cone, Calcium, Axon guidance, Cytoskeleton, Endoplasmic reticulum (ER), Microtubules, Actin |
| Research Division: | Medical and Health Sciences |
| Research Group: | Neurosciences |
| Research Field: | Cellular Nervous System |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Gasperini, RJ (Dr Rob Gasperini) |
| Author: | Pavez, M (Miss Macarena Pavez) |
| Author: | Thompson, AC (Mr Adrian Thompson) |
| Author: | Mitchell, Camila (Ms Camila Mitchell) |
| Author: | Young, KM (Dr Kaylene Young) |
| Author: | Foa, L (Associate Professor Lisa Foa) |
| ID Code: | 120146 |
| Year Published: | In Press |
| Deposited By: | Medicine (Discipline) |
| Deposited On: | 2017-08-11 |
| Last Modified: | 2017-08-11 |
| Downloads: | 0 |
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