eCite Digital Repository

How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?


Gasperini, RJ and Pavez, MP and Thompson, AC and Mitchell, Camila and Hardy, H and Young, KM and Chilton, JK and Foa, L, How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?, Molecular and Cellular Neurosciences, 84 pp. 29-35. ISSN 1044-7431 (2017) [Refereed Article]


Copyright Statement

Copyright 2017 Crown Copyright. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

DOI: doi:10.1016/j.mcn.2017.07.006


The precision with which neurons form connections is crucial for the normal development and function of the nervous system. The development of neuronal circuitry in the nervous system is accomplished by axon pathfinding: a process where growth cones guide axons through the embryonic environment to connect with their appropriate synaptic partners to form functional circuits. Despite intense efforts over many years to understand how this process is regulated, the complete repertoire of molecular mechanisms that govern the growth cone cytoskeleton and hence motility, remain unresolved. A central tenet in the axon guidance field is that calcium signals regulate growth cone behaviours such as extension, turning and pausing by regulating rearrangements of the growth cone cytoskeleton. Here, we provide evidence that not only the amplitude of a calcium signal is critical for growth cone motility but also the source of calcium mobilisation. We provide an example of this idea by demonstrating that manipulation of calcium signalling via L-type voltage gated calcium channels can perturb sensory neuron motility towards a source of netrin-1. Understanding how calcium signals can be transduced to initiate cytoskeletal changes represents a significant gap in our current knowledge of the mechanisms that govern axon guidance, and consequently the formation of functional neural circuits in the developing nervous system.

Item Details

Item Type:Refereed Article
Keywords:Growth cone, Calcium, Axon guidance, Cytoskeleton, Endoplasmic reticulum (ER), Microtubules, Actin
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Gasperini, RJ (Dr Rob Gasperini)
UTAS Author:Pavez, MP (Miss Macarena Pavez)
UTAS Author:Thompson, AC (Mr Adrian Thompson)
UTAS Author:Mitchell, Camila (Ms Camila Mitchell)
UTAS Author:Young, KM (Professor Kaylene Young)
UTAS Author:Foa, L (Professor Lisa Foa)
ID Code:120146
Year Published:2017
Web of Science® Times Cited:42
Deposited By:Medicine
Deposited On:2017-08-11
Last Modified:2022-08-23
Downloads:137 View Download Statistics

Repository Staff Only: item control page