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TNF-alpha inhibitors for ankylosing spondylitis


Maxwell, LJ and Zochling, J and Boonen, A and Singh, JA and Veras, MMS and Ghogomu, ET and Jandu, MB and Tugwell, P and Wells, GA, TNF-alpha inhibitors for ankylosing spondylitis, Cochrane Database of Systematic Reviews, (4) Article CD005468. ISSN 1469-493X (2015) [Refereed Article]


Copyright Statement

Copyright 2015 The Cochrane Collaboration

DOI: doi:10.1002/14651858.CD005468.pub2


Background: TNF (tumor necrosis factor)-alpha inhibitors block a key protein in the inflammatory chain reaction responsible for joint inflammation, pain, and damage in ankylosing spondylitis.

Objectives: To assess the benefit and harms of adalimumab, etanercept, golimumab, and infliximab (TNF-alpha inhibitors) in peoplewith ankylosing spondylitis.

Search methods: We searched the following databases to January 26, 2009: MEDLINE (from 1966); EMBASE (from 1980); the Cochrane Central Register of Controlled Trials (CENTRAL; 2008, Issue 4); ACP Journal Club; CINAHL (from1982); and ISIWeb of Knowledge (from 1900). We ran updated searches in May 2012, October 2013, and in June 2014 for McMaster PLUS. We searched major regulatory agencies for safety warnings and clinicaltrials. gov for registered trials.

Selection criteria: Randomized controlled trials (RCTs) comparing adalimumab, etanercept, golimumab and infliximab to placebo, other drugs or usual care in patients with ankylosing spondylitis, reported in abstract or full-text.

Data collection and analysis: Two authors independently assessed search results, risk of bias, and extracted data. We conducted Bayesian mixed treatment comparison (MTC) meta-analyses using WinBUGS software. To investigate a class-effect of harms across biologics, we pooled harms data using Review Manager 5.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zochling, J (Dr Jane Zochling)
ID Code:120128
Year Published:2015
Web of Science® Times Cited:147
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-08-10
Last Modified:2018-05-07
Downloads:612 View Download Statistics

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