Pulkki-Raback, L and Elovainio, M and Hakulinen, C and Lipsanen, J and Kubzansky, LD and Hintsanen, M and Savelieva, K and Serlachius, A and Magnussen, CG and Sabin, MA and Burgner, DP and Lehtimaki, T and Jokinen, E and Ronnemaa, T and Mikkila, V and Jula, A and Hutri-Kahonen, N and Viikari, J and Keltikangas-Jarvinen, L and Raitakari, O and Juonala, M, Positive psychosocial factors in childhood predicting lower risk for adult type 2 diabetes: the Cardiovascular Risk in Young Finns Study, 1980-2012, American Journal of Preventive Medicine, 52, (6) pp. e157-e164. ISSN 0749-3797 (2017) [Refereed Article]
Copyright 2017 American Journal of Preventive Medicine
Methods: A cohort of 3,596 Finnish children was followed into adulthood over 32 years. An overall positive psychosocial score, consisting of six subdomains, was measured at study baseline (1980). Relative risk ratios and multilevel growth curve modeling were used to examine associations of the psychosocial score with Type 2 diabetes (2012) and glucose trajectories (1986-2012). The mediating effect by BMI was examined using mediation analysis. The analyses were conducted between June 2015 and January 2016.
Results: There was a 21% decrease in the rate of Type 2 diabetes (relative risk ratio, 0.79; 95% CI=0.66, 0.94) for each 1-SD increase in the positive psychosocial score after adjustment for childhood cardiovascular risk factors and dietary behaviors. Adult BMI mediated 52% and weight gain mediated 25% of the association. The growth curve model showed healthier glucose trajectories (age X psychosocial score interaction, b= -0.01; p=0.010) for participants with higher versus lower positive psychosocial score in childhood.
Conclusions: Positive psychosocial environment in childhood seems to have beneficial influences on the risk for Type 2 diabetes over the life span. RCTs will be required to see if interventions directed at early-life circumstances are warranted.
|Item Type:||Refereed Article|
|Keywords:||psychosocial factors, childhood, type 2 diabetes, cohort|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Author:||Magnussen, CG (Dr Costan Magnussen)|
|Funding Support:||National Health and Medical Research Council (1098369)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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