Niewiadomski, O and Studd, C and Wilson, J and Williams, J and Hair, C and Knight, R and Prewett, E and Dabkowski, P and Alexander, S and Allen, B and Dowling, D and Connell, W and Desmond, P and Bell, S, Influence of food and lifestyle on the risk of developing inflammatory bowel disease, Internal Medicine Journal, 46, (6) pp. 669-676. ISSN 1444-0903 (2016) [Refereed Article]
Copyright 2016 Royal Australasian College of Physicians
AIM: To study these exposures prior to the development of IBD in a population-based cohort.
METHOD: One hundred and thirty-two incident cases (81 Crohn disease (CD) and 51 ulcerative colitis (UC)) from an IBD registry and 104 controls replied to the International Organization of Inflammatory Bowel Diseases environmental questionnaire. This included 87 questions about pre-illness exposures that included childhood illnesses, vaccinations, breastfeeding, house amenities, pets and swimming, diet and smoking.
RESULTS: The factors associated with CD included smoking (odds ratio (OR): 1.42, confidence interval (CI): 1-2.02, P = 0.029); childhood events, including tonsillectomy (OR: 1.74, CI: 1.15-2.6, P = 0.003) and chicken pox infection (OR: 3.89, CI: 1.61-9.4, P = 0.005) and pre-diagnosis intake of frequent fast food (OR: 2.26, CI: 1.76-4.33, P = 0.003). In UC, the risk factors included smoking (OR: 1.39, CI: 1.1-1.92, P = 0.026) and pre-diagnosis intake of frequent fast food (OR: 2.91, CI: 1.54-5.58, P < 0.001), and high caffeine intake was protective (OR: 0.51, 95% CI: 0.3-0.87, P = 0.002). Other protective exposures for UC included high fruit intake (OR: 0.59, CI: 0.4-0.88, P = 0.003) and having pets as a child (OR: 0.36, CI: 0.2-0.79, P = 0.001).
CONCLUSION: This first Australian population-based study of environmental risk factors confirms that smoking, childhood immunological events and dietary factors play a role in IBD development; while high caffeine intake and pet ownership offer a protective effect.
|Item Type:||Refereed Article|
|Keywords:||Crohn disease, aetiology, environmental factors, epidemiology, inflammatory bowel disease, ulcerative colitis|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Objective Field:||Behaviour and Health|
|Author:||Studd, C (Dr Corrie Studd)|
|Web of Science® Times Cited:||8|
|Deposited By:||Menzies Institute for Medical Research|
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