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Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men
journal contribution
posted on 2023-05-19, 08:35 authored by Edwards, LM, Murray, AJ, Holloway, CJ, Carter, EE, Kemp, GJ, Codreanu, I, Brooker, H, Tyler, DJ, Robbins, PA, Clarke, KWe recently showed that a short-term high-fat diet blunted exercise performance in rats, accompanied by increased uncoupling protein levels and greater respiratory uncoupling. In this study, we investigated the effects of a similar diet on physical and cognitive performance in humans. Twenty sedentary men were assessed when consuming a standardized, nutritionally balanced diet (control) and after 7 d of consuming a diet comprising 74% kcal from fat. Efficiency was measured during a standardized exercise task, and cognition was assessed using a computerized assessment battery. Skeletal muscle mitochondrial function was measured using 31 P magnetic resonance spectroscopy. The diet increased mean ± SE plasma free fatty acids by 44% (0.32±0.03 vs. 0.46±0.05 mM; P < 0.05) and decreased whole-body efficiency by 3% (21±1 vs. 18±1%; P < 0.05), although muscle uncoupling protein (UCP3) content and maximal mitochondrial function were unchanged. High-fat diet consumption also increased subjects' simple reaction times (P < 0.01) and decreased power of attention (P < 0.01). Thus, we have shown that a high-fat diet blunts wholebody efficiency and cognition in sedentary men. We suggest that this effect may be due to increased respiratory uncoupling.
History
Publication title
FASEB JournalVolume
25Pagination
1088-1096ISSN
0892-6638Department/School
Menzies Institute for Medical ResearchPublisher
Federation of American Societies for Experimental BiologyPlace of publication
United StatesRepository Status
- Restricted