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Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men

Citation

Edwards, LM and Murray, AJ and Holloway, CJ and Carter, EE and Kemp, GJ and Codreanu, I and Brooker, H and Tyler, DJ and Robbins, PA and Clarke, K, Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men, FASEB Journal, 25, (3) pp. 1088-1096. ISSN 0892-6638 (2011) [Refereed Article]

DOI: doi:10.1096/fj.10-171983

Abstract

We recently showed that a short-term high-fat diet blunted exercise performance in rats, accompanied by increased uncoupling protein levels and greater respiratory uncoupling. In this study, we investigated the effects of a similar diet on physical and cognitive performance in humans. Twenty sedentary men were assessed when consuming a standardized, nutritionally balanced diet (control) and after 7 d of consuming a diet comprising 74% kcal from fat. Efficiency was measured during a standardized exercise task, and cognition was assessed using a computerized assessment battery. Skeletal muscle mitochondrial function was measured using 31 P magnetic resonance spectroscopy. The diet increased mean SE plasma free fatty acids by 44% (0.32±0.03 vs. 0.460.05 mM; P < 0.05) and decreased whole-body efficiency by 3% (211 vs. 181%; P < 0.05), although muscle uncoupling protein (UCP3) content and maximal mitochondrial function were unchanged. High-fat diet consumption also increased subjects' simple reaction times (P < 0.01) and decreased power of attention (P < 0.01). Thus, we have shown that a high-fat diet blunts wholebody efficiency and cognition in sedentary men. We suggest that this effect may be due to increased respiratory uncoupling.

Item Details

Item Type:Refereed Article
Keywords:exercise, magnetic resonance, mitochondria, nutrition
Research Division:Medical and Health Sciences
Research Group:Medical Physiology
Research Field:Systems Physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Edwards, LM (Dr Lindsay Edwards)
ID Code:119304
Year Published:2011
Web of Science® Times Cited:40
Deposited By:Medicine (Discipline)
Deposited On:2017-07-31
Last Modified:2017-07-31
Downloads:0

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