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Antibiotic choice may not explain poorer outcomes in patients with Staphylococcus aureus bacteremia and high vancomycin minimum inhibitory concentrations


Holmes, NE and Turnidge, JD and Munckhof, WJ and Robinson, JO and Korman, TM and O'Sullivan, MVN and Anderson, TL and Roberts, SA and Gao, W and Christiansen, KJ and Coombs, GW and Johnson, PDR and Howden, BP, Antibiotic choice may not explain poorer outcomes in patients with Staphylococcus aureus bacteremia and high vancomycin minimum inhibitory concentrations, Journal of Infectious Diseases, 204, (3) pp. 340-347. ISSN 0022-1899 (2011) [Refereed Article]

Copyright Statement

Copyright 2011 The Author

DOI: doi:10.1093/infdis/jir270


Background: There are concerns about reduced efficacy of vancomycin in patients with Staphylococcus aureus bacteremia (SAB), especially when the minimum inhibitory concentration (MIC) nears the upper limit of the susceptible range. Methods: We examined the relationship between antibiotic treatment, 30-day mortality, and microbiologic parameters in a large Australasian cohort of patients with SAB. Results: We assessed 532 patients with SAB from 8 hospitals. All patients with methicillin-resistant S. aureus (MRSA) bacteremia were treated with vancomycin, and patients with methicillin-susceptible S. aureus (MSSA) bacteremia received either flucloxacillin or vancomycin. Increasing vancomycin MIC was associated with increased mortality in vancomycin-treated patients. However, even in patients with MSSA bacteremia treated with flucloxacillin, mortality was also higher if the vancomycin Etest MIC of their isolate was > 1.5 μg/mL, compared with thosewith lower MIC isolates (26.8% vs 12.2%; P < .001). After adjustment in a multivariate model, age, hospital-onset SAB and vancomycin MIC were independently associated with mortality, butmethicillin resistance and antibiotic choice were not. Conclusions: We have confirmed an association between higher vancomycin MIC and increased mortality in patients with SAB, but surprisingly this relationship was not related to the antibiotic treatment received, suggesting that the use of vancomycin per se is not responsible for the poorer outcome. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

Item Details

Item Type:Refereed Article
Keywords:antibiotic agent, flucloxacillin, meticillin, vancomycin
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Infectious diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Anderson, TL (Dr Tara Anderson)
ID Code:119257
Year Published:2011
Web of Science® Times Cited:181
Deposited By:Medicine
Deposited On:2017-07-28
Last Modified:2017-10-24

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