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Refuelling of vehicles, the use of wood burners and the risk of acute lymphoblastic leukaemia in childhood

Citation

Bailey, HD and de Klerk, NH and Frischi, L and Attia, J and Daubenton, JD and Armstrong, BK and Milne, E, Refuelling of vehicles, the use of wood burners and the risk of acute lymphoblastic leukaemia in childhood, Paediatric and Perinatal Epidemiology, 25, (6) pp. 528-539. ISSN 0269-5022 (2011) [Refereed Article]

Copyright Statement

2011 Blackwell Publishing

DOI: doi:10.1111/j.1365-3016.2011.01224.x

Abstract

It is plausible that exposure of the parents before birth or of the child to sources of benzene increases the risk of childhood acute lymphoblastic leukaemia (ALL). The aim of this analysis was to investigate whether refuelling a vehicle with petrol before birth or burning wood to heat the home before or after the child's birth increased the risk of childhood ALL. Data from 389 cases and 876 frequency-matched controls were analysed using unconditional logistic regression, adjusting for study matching factors and potential confounders. The odds ratio (OR) for the mother ever refuelling a vehicle with petrol for non-occupational purposes before or during the pregnancy was 0.97 [95% confidence interval (CI) 0.69, 1.38]. The OR for the father for this exposure in the year before conception was 0.88 [95% CI 0.52, 1.48]. The OR for use of a closed wood burner to heat the home in the year before or during pregnancy was 1.41 [95% CI 1.02, 1.94] and 1.25 [95% CI 0.92, 1.70] after birth. We found no evidence that non-occupational refuelling a vehicle with petrol in the year before or during pregnancy increased the risk of ALL in the offspring. There was weak evidence that burning wood in a closed burner to heat the home increased the risk, but there was no dose-response relationship and chance could explain the finding.

Item Details

Item Type:Refereed Article
Keywords:home heating, benzene, petrol, childhood cancer, acute lymphoblastic leukaemia
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Oncology and Carcinogenesis not elsewhere classified
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Daubenton, JD (Associate Professor John Daubenton)
ID Code:119237
Year Published:2011
Web of Science® Times Cited:6
Deposited By:Medicine (Discipline)
Deposited On:2017-07-28
Last Modified:2017-09-04
Downloads:0

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