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ELectrokinetic traps for integrated biological sample analysis


Shallan, A and Guijt, RM and Breadmore, MC, ELectrokinetic traps for integrated biological sample analysis, Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 26-30 October, San Antonio, Texas, USA, pp. 1467-1469. ISBN 978-097980647-6 (2014) [Refereed Conference Paper]

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Copyright 2014 Chemical and Biological Microsystems Society (CBMS)

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A new device integrating diverse electrokinetic steps is presented to extract and enrich analytes directly from blood followed by electrophoretic separation. Two sequentially coupled nanojunctions with different pore size formed a trap with selective ion transport properties. The balance between depletion forces near the nanojunctions and/or apparent electromigration can be tuned for analysis of proteins, DNA, or pharmaceuticals. Here, we demonstrate the analysis of ampicillin from blood within 5 min. The obtained linear range of 2.5-20 μg/mL covers the therapeutically relevant concentration for treating sepsis.

Item Details

Item Type:Refereed Conference Paper
Keywords:electrophoresis, polydimethylsiloxane breakdown, sample preparation
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Shallan, A (Ms Aliaa Shallan)
UTAS Author:Guijt, RM (Dr Rosanne Guijt)
UTAS Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:119159
Year Published:2014
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2017-07-27
Last Modified:2018-03-08

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