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On-chip nanofilters for biological sample pre-treatment for electrophoretic analysis of small molecules in whole blood

conference contribution
posted on 2023-05-23, 12:20 authored by Shallan, A, Adam GaudryAdam Gaudry, Rosanne Guijt, Michael BreadmoreMichael Breadmore
We present a new method for on-chip sample pretreatment based on size and charge exclusion in nanochannels formed by simple electric breakdown of poly(dimethylsiloxane) (PDMS). In contrast to previously published methods, control over pore size was achieved by setting a current limit during the breakdown step, allowing selective transport through the nanopores of different size molecules. Finally, we demonstrate the application of this method for the direct analysis of quinine in whole blood samples at clinically relevant concentrations.

History

Publication title

Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Pagination

1168-1170

ISBN

978-097980645-2

Department/School

School of Natural Sciences

Publisher

Chemical and Biological Microsystems Society

Place of publication

Washington, DC, USA

Event title

16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Event Venue

Okinawa, Japan

Date of Event (Start Date)

2012-10-28

Date of Event (End Date)

2012-11-01

Rights statement

Copyright 2012 Chemical and Biological Microsystems Society (CBMS)

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the health sciences

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