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On-chip nanofilters for biological sample pre-treatment for electrophoretic analysis of small molecules in whole blood

Citation

Shallan, A and Gaudry, A and Guijt, R and Breadmore, M, On-chip nanofilters for biological sample pre-treatment for electrophoretic analysis of small molecules in whole blood, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 28 October - 01 November, Okinawa, Japan, pp. 1168-1170. ISBN 978-097980645-2 (2012) [Refereed Conference Paper]


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Copyright Statement

Copyright 2012 Chemical and Biological Microsystems Society (CBMS)

Official URL: http://www.microtas12.org/index.html

Abstract

We present a new method for on-chip sample pretreatment based on size and charge exclusion in nanochannels formed by simple electric breakdown of poly(dimethylsiloxane) (PDMS). In contrast to previously published methods, control over pore size was achieved by setting a current limit during the breakdown step, allowing selective transport through the nanopores of different size molecules. Finally, we demonstrate the application of this method for the direct analysis of quinine in whole blood samples at clinically relevant concentrations.

Item Details

Item Type:Refereed Conference Paper
Keywords:nanochannels, sample pre-treatment, blood, pharmaceuticals
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Pharmaceutical Sciences
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Shallan, A (Ms Aliaa Shallan)
Author:Gaudry, A (Mr Adam Gaudry)
Author:Guijt, R (Dr Rosanne Guijt)
Author:Breadmore, M (Professor Michael Breadmore)
ID Code:119080
Year Published:2012
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2017-07-26
Last Modified:2017-10-05
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