eCite Digital Repository
Afterload dependence of right ventricular myocardial strain
Citation
Wright, L and Negishi, K and Dwyer, N and Wahi, S and Marwick, TH, Afterload dependence of right ventricular myocardial strain, Journal of the American Society of Echocardiography, 30, (7) pp. 676-684. ISSN 0894-7317 (2017) [Refereed Article]
Copyright Statement
Copyright 2017 by the American Society of Echocardiography. Copyright 2017. Elsevier Inc. All rights reserved.
DOI: doi:10.1016/j.echo.2017.03.002
Abstract
Methods: Sequential echocardiograms were collected retrospectively at two time points between 2005 and 2015 in 187 patients (71% women; mean age, 63 ± 14 years) undergoing pulmonary vasodilator therapy for group 1 PAH. Patients were either studied during PAH therapy (n = 111) or before and after treatment initiation (n = 76). Standard measurements of RV and left ventricular function and PASP were performed, and speckle-tracking strain was used to calculate RVFWS. The linear response of RVFWS to afterload (PASP) was assessed using a standard regression equation. Because it is unclear if the response might be nonlinear, a quadratic association (PASP squared) was also used in the regression model.
Results: At visit 1, patients with PAH showed impaired functional capacity (mean 6-min walk distance, 371 ± 131 m), increased PASP (mean, 54 ± 26 mm Hg), and borderline RVFWS (mean, 18 ± 6%). Patients before PAH therapy showed more pronounced reduction in 6-min walk distance (mean, 302 ± 136 m) and RVFWS (mean, 16 ± 5%). RVFWS at baseline was associated with PASP (R2 = 0.25, P = .001), RV end-diastolic area (R2 = 0.36, P < .001), and fractional area change (R2 = 0.21, P < .001). Change in RVFWS was more strongly associated with ΔPASP (std β = -0.20, P = .02) than ΔPASP squared (std β = 0.11, P = .20). RVFWS showed strength over fractional area change for sequential RV assessment over a range of PASP changes.
Conclusions: Afterload changes should be taken into account in the evaluation of RVFWS during PAH follow-up, with the relationship to PASP likely to be linear.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | fractional area change, pulmonary artery systolic pressure, right ventricle, strain |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Wright, L (Ms Leah Wright) |
UTAS Author: | Negishi, K (Dr Kazuaki Negishi) |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
ID Code: | 118571 |
Year Published: | 2017 |
Web of Science® Times Cited: | 14 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2017-07-13 |
Last Modified: | 2022-08-25 |
Downloads: | 0 |
Repository Staff Only: item control page