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Effects of exercise on type 2 diabetes mellitus-related cognitive impairment and dementia


Callisaya, M and Nosaka, K, Effects of exercise on type 2 diabetes mellitus-related cognitive impairment and dementia, Journal of Alzheimer's Disease, 59, (2) pp. 503-513. ISSN 1387-2877 (2017) [Refereed Article]

Copyright Statement

2017 IOS Press and the authors. All rights reserved

DOI: doi:10.3233/JAD-161154


Cognitive impairment and dementia are common contributors to institutionalization and loss of quality of life in older people. Both type 2 diabetes mellitus (T2DM) and physical inactivity are prevalent and important modifiable risk factors for developing dementia. Physical activity is recommended in the management of T2DM, and there is growing evidence that exercise, a subgroup of physical activity, is also beneficial for maintaining and improving brain structure and function. This paper reviews the evidence for a benefit of exercise on T2DM related cognitive impairment and dementia. In addition, the type (e.g., aerobic, resistance), intensity, duration, and frequency of exercise are discussed. This review shows that although exercise has known benefits on the mechanisms linking T2DM to dementia, there are very few randomized controlled trials examining whether this is the case. It is concluded that the uptake of exercise for the brain has great potential to improve quality of life and provide significant cost savings, but further research is warranted to clarify the effects of exercise on T2DM and those on dementia.

Item Details

Item Type:Refereed Article
Keywords:aerobic exercise, brain health, cognitive function, eccentric exercise, physical activity, resistance exercise
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Geriatrics and gerontology
Objective Division:Health
Objective Group:Specific population health (excl. Indigenous health)
Objective Field:Health related to ageing
UTAS Author:Callisaya, M (Dr Michele Callisaya)
ID Code:118568
Year Published:2017
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-07-13
Last Modified:2018-06-07

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