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Host-Parasite Interactions
Citation
Korner, H and Hu, S and Bogdan, C, Host-Parasite Interactions, Molecular Parasitology: Protozoan Parasites and their Molecules, Springer, J Walochnik & M Duchene (ed), Vienna, Austria, pp. 409-430. ISBN 978-3-7091-1415-5 (2016) [Research Book Chapter]
Copyright Statement
Copyright 2016 Springer-Verlag Wien
DOI: doi:10.1007/978-3-7091-1416-2_13
Abstract
© Springer-Verlag Wien 2016. Ontogeny and differentiation of cells of the monocyte/macrophage lineage are currently subjects of intense research. The concept of the macrophage as “simple” phagocytic cell has undergone profound changes. It has now been established that this myeloid lineage of cells is phenotypically and functionally much more diverse and exerts a much wider influence on the immune response than previously thought. How have these new findings changed our perception of the role of monocytes and macrophages in parasitic diseases? There is now strong evidence that macrophages fulfill organ-specific differential functions, exert activating as well as inhibitory effects on the adaptive immune response, and exist in a whole range of different activation statuses which show a high degree of plasticity. In the present chapter, we will not only review the pertinent literature on these new developments but also bring it into relation to the anti-infectious immune response, focusing on four parasitic diseases (trypanosomiasis, toxoplasmosis, malaria, and leishmaniasis) as examples.
Item Details
Item Type: | Research Book Chapter |
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Research Division: | Biomedical and Clinical Sciences |
Research Group: | Immunology |
Research Field: | Immunology not elsewhere classified |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Korner, H (Professor Heinrich Korner) |
UTAS Author: | Hu, S (Miss Shanshan Hu) |
ID Code: | 118552 |
Year Published: | 2016 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2017-07-13 |
Last Modified: | 2017-10-16 |
Downloads: | 0 |
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