Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS)

Laitinen, TT; Ruohonen, S; Juonala, M; Magnussen, CG; Mikkila, V; Mikola, H; Hutri-Kahonen, N; Laitinen, T; Tossavainen, P; Jokinen, E; Niinikoski, H; Jula, A; Viikari, JSA; Ronnemaa, T; Raitakari, OT; Pahkala, K

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Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS)

Citation

Laitinen, TT and Ruohonen, S and Juonala, M and Magnussen, CG and Mikkila, V and Mikola, H and Hutri-Kahonen, N and Laitinen, T and Tossavainen, P and Jokinen, E and Niinikoski, H and Jula, A and Viikari, JSA and Ronnemaa, T and Raitakari, OT and Pahkala, K, Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS), International Journal of Cardiology, 230 pp. 304-309. ISSN 0167-5273 (2017) [Refereed Article]

Copyright Statement

DOI: doi:10.1016/j.ijcard.2016.12.117

Abstract

Background: Ideal cardiovascular health (CVH), defined by the American Heart Association, is associated with incident cardiovascular disease in adults. However, association of the ideal CVH in childhood with current and future cardiac structure and function has not been studied.

Methods and Results: The sample comprised 827 children participating in the longitudinal Special Turku Coronary Risk Factor Intervention Project (STRIP) and The Cardiovascular Risk in Young Finns Study (YFS). In STRIP, complete data on the seven ideal CVH metrics and left ventricular (LV) mass measured with echocardiography were available at the age of 15 (n = 321), 17 (n = 309) and 19 (n = 283) years. In YFS, the cohort comprised children aged 12-18years (n = 506) with complete ideal CVH metrics data from childhood and 25 years later in adulthood, and echocardiography performed in adulthood. In STRIP, ideal CVH score was inversely associated with LV mass during childhood (P = 0.036). In YFS, childhood ideal CVH score was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume in adulthood (all P < 0.01). In addition, improvement of the ideal CVH score between childhood and adulthood was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume (all P ≤ 0.03).

Conclusions: Childhood ideal CVH score has a long-lasting effect on cardiac structure and function, and the association is evident already in childhood. Our findings support targeting the ideal CVH metrics as part of primordial prevention of cardiovascular diseases.

Item Details

Item Type:	Refereed Article
Keywords:	left ventricular mass, risk factors, diastolic dysfunction, echocardiography, cardiovascular disease prevention
Research Division:	Medical and Health Sciences
Research Group:	Public Health and Health Services
Research Field:	Epidemiology
Objective Division:	Health
Objective Group:	Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:	Cardiovascular System and Diseases
UTAS Author:	Magnussen, CG (Dr Costan Magnussen)
ID Code:	118516
Year Published:	2017
Web of Science^® Times Cited:	7
Deposited By:	Menzies Institute for Medical Research
Deposited On:	2017-07-13
Last Modified:	2018-06-07
Downloads:	0

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