Laitinen, TT and Ruohonen, S and Juonala, M and Magnussen, CG and Mikkila, V and Mikola, H and Hutri-Kahonen, N and Laitinen, T and Tossavainen, P and Jokinen, E and Niinikoski, H and Jula, A and Viikari, JSA and Ronnemaa, T and Raitakari, OT and Pahkala, K, Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS), International Journal of Cardiology, 230 pp. 304-309. ISSN 0167-5273 (2017) [Refereed Article]
METHODS AND RESULTS: The sample comprised 827 children participating in the longitudinal Special Turku Coronary Risk Factor Intervention Project (STRIP) and The Cardiovascular Risk in Young Finns Study (YFS). In STRIP, complete data on the seven ideal CVH metrics and left ventricular (LV) mass measured with echocardiography were available at the age of 15 (n=321), 17 (n=309) and 19 (n=283) years. In YFS, the cohort comprised children aged 12-18years (n=506) with complete ideal CVH metrics data from childhood and 25years later in adulthood, and echocardiography performed in adulthood. In STRIP, ideal CVH score was inversely associated with LV mass during childhood (P=0.036). In YFS, childhood ideal CVH score was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume in adulthood (all P<0.01). In addition, improvement of the ideal CVH score between childhood and adulthood was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume (all P≤0.03).
CONCLUSIONS: Childhood ideal CVH score has a long-lasting effect on cardiac structure and function, and the association is evident already in childhood. Our findings support targeting the ideal CVH metrics as part of primordial prevention of cardiovascular diseases.
|Item Type:||Refereed Article|
|Keywords:||Left ventricular mass, Risk factors, Diastolic dysfunction, Echocardiography, Cardiovascular disease prevention|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Magnussen, CG (Dr Costan Magnussen)|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page