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Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound

Citation

Blackwood, SJ and Dwyer, RM and Bradley, EA and Keske, MA and Richards, SM and Rattigan, S, Determination of skeletal muscle microvascular flowmotion with contrast-enhanced ultrasound, Ultrasound in Medicine and Biology, 43, (9) pp. 2013-2023. ISSN 0301-5629 (2017) [Refereed Article]

Copyright Statement

2017 World Federation for Ultrasound in Medicine & Biology

DOI: doi:10.1016/j.ultrasmedbio.2017.05.012

Abstract

Most methods of assessing flowmotion (rhythmic oscillation of blood flow through tissue) are limited to small sections of tissue and are invasive in tissues other than skin. To overcome these limitations, we adapted the contrast-enhanced ultrasound (CEUS) technique to assess microvascular flowmotion throughout a large region of tissue, in a non-invasive manner and in real time. Skeletal muscle flowmotion was assessed in anaesthetised Sprague Dawley rats, using CEUS and laser Doppler flowmetry (LDF) for comparison. Wavelet transformation of CEUS and LDF data was used to quantify flowmotion. The α-adrenoceptor antagonist phentolamine was infused to predictably blunt the neurogenic component of flowmotion. Both techniques identified similar flowmotion patterns, validating the use of CEUS to assess flowmotion. This study demonstrates for the first time that the novel technique of CEUS can be adapted for determination of skeletal muscle flowmotion in large regions of skeletal muscle.

Item Details

Item Type:Refereed Article
Keywords:contrast enhanced ultrasound, flowmotion, laser Doppler flowmetry
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Diabetes
Author:Blackwood, SJ (Ms Sarah Blackwood)
Author:Dwyer, RM (Dr Renee Dwyer)
Author:Bradley, EA (Miss Eloise Bradley)
Author:Keske, MA (Dr Michelle Keske)
Author:Richards, SM (Dr Stephen Richards)
Author:Rattigan, S (Professor Stephen Rattigan)
ID Code:118503
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-07-13
Last Modified:2017-08-04
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