Nuotio, J and Pitkanen, N and Magnussen, CG and Buscot, MJ and Venalainen, MS and Elo, LL and Jokinen, E and Laitinen, T and Taittonen, L and Hutri-Kahonen, N and Lyytikainen, LP and Lehtimaki, T and Viikari, JS and Juonala, M and Raitakari, OT, Prediction of adult dyslipidemia using genetic and childhood clinical risk factors: The Cardiovascular Risk in Young Finns Study, Circulation - Cardiovascular Genetics, 10, (3) Article e001604. ISSN 1942-3268 (2017) [Refereed Article]
Methods and Results: Two thousand four hundred and twenty-two participants of the Cardiovascular Risk in Young Finns Study who had participated in 2 surveys held during childhood (in 1980 when aged 3-18 years and in 1986) and at least once in a follow-up study in adulthood (2001, 2007, and 2011) were included. We examined whether inclusion of a lipid-specific weighted genetic risk score based on 58 single-nucleotide polymorphisms for low-density lipoprotein cholesterol, 71 single-nucleotide polymorphisms for high-density lipoprotein cholesterol, and 40 single-nucleotide polymorphisms for triglycerides improved the prediction of adult dyslipidemia compared with clinical childhood risk factors. Adjusting for age, sex, body mass index, physical activity, and smoking in childhood, childhood lipid levels, and weighted genetic risk scores were associated with an increased risk of adult dyslipidemia for all lipids. Risk assessment based on 2 childhood lipid measures and the lipid-specific weighted genetic risk scores improved the accuracy of predicting adult dyslipidemia compared with the approach using only childhood lipid measures for low-density lipoprotein cholesterol (area under the receiver-operating characteristic curve 0.806 versus 0.811; P=0.01) and triglycerides (area under the receiver-operating characteristic curve 0.740 versus area under the receiver-operating characteristic curve 0.758; P<0.01). The overall net reclassification improvement and integrated discrimination improvement were significant for all outcomes.
Conclusions: The inclusion of weighted genetic risk scores to lipid-screening programs in childhood could modestly improve the identification of those at highest risk of dyslipidemia in adulthood.
|Item Type:||Refereed Article|
|Keywords:||cholesterol, dyslipidemias, genetics, lipids, risk factor|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Magnussen, CG (Dr Costan Magnussen)|
|Author:||Buscot, MJ (Miss Marie-Jeanne Buscot)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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