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Thyroid hormone related gene transcription in southern sand flathead (Platycephalus bassensis) is associated with environmental mercury and arsenic exposure

Citation

Fu, D and Leef, M and Nowak, B and Bridle, A, Thyroid hormone related gene transcription in southern sand flathead (Platycephalus bassensis) is associated with environmental mercury and arsenic exposure, Ecotoxicology, 26, (5) pp. 600-612. ISSN 0963-9292 (2017) [Refereed Article]


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DOI: doi:10.1007/s10646-017-1793-4

Abstract

Arsenic (As) and mercury (Hg) are ubiquitous elements known to disrupt thyroid function in vertebrates. To explore the underlying mechanisms of Hg and As on the fish thyroid system, we investigated the associations between muscle concentrations of Hg and As with thyroid-related gene transcription in flathead (Platycephalus bassensis) from a contaminated estuary. We sampled fish at several sites to determine the hepatic expression of genes including deiodinases (D1 and D2), transthyretin (TTR), thyroid hormone receptors (TRα and TRβ) and related them to Hg and As levels in the same individuals. Negative correlations were observed between Hg levels and D2, TTR, TRα and TRβ, whereas positive associations were found between As concentrations and TTR and TRβ. These results suggest that Hg and As exposures from environmental pollution affect the regulation of genes important for normal thyroid function in fish. These thyroid-related genes could be used as biomarkers for monitoring environmental thyroid-hormone disrupting chemicals.

Item Details

Item Type:Refereed Article
Keywords:thyroid-related genes, mercury, arsenic, biomarker, fish
Research Division:Agricultural and Veterinary Sciences
Research Group:Fisheries Sciences
Research Field:Aquaculture
Objective Division:Animal Production and Animal Primary Products
Objective Group:Fisheries - Aquaculture
Objective Field:Fisheries - Aquaculture not elsewhere classified
Author:Fu, D (Mr Dingkun Fu)
Author:Leef, M (Dr Melanie Leef)
Author:Nowak, B (Professor Barbara Nowak)
Author:Bridle, A (Dr Andrew Bridle)
ID Code:118348
Year Published:2017
Deposited By:Centre for Fisheries and Aquaculture
Deposited On:2017-07-11
Last Modified:2017-07-11
Downloads:0

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