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The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection

Citation

Li, X and Lyons, AB and Woods, GM and Korner, H, The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection, Immunobiology, 222, (8-9) pp. 913-917. ISSN 0171-2985 (2017) [Refereed Article]

Copyright Statement

2017 Elsevier GmbH. All rights reserved.

DOI: doi:10.1016/j.imbio.2017.05.012

Abstract

During an immune response inflammatory macrophages with their wide variety of effector mechanisms including the expression of inducible nitric oxide synthase play an important part in the defense against invading pathogens. The inflammatory phenotype requires the presence of TNF which suppresses alternative activation. In the bacterial Listeria monocytogenes infection model inflammatory macrophages are crucial for protection. After infection, TNF-deficient hosts have a similar number of splenic macrophages but die rapidly. A more detailed analysis of these cells showed that while inducible nitric oxide synthase is expressed at a comparable level TNF-deficient macrophages show an increased expression of Arginase 1.

Item Details

Item Type:Refereed Article
Keywords:Macrophages, Tumor necrosis factor, Cell differentiation, Listeria monocytogenes
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Innate Immunity
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Li, X (Ms Amy Li)
Author:Lyons, AB (Dr Bruce Lyons)
Author:Woods, GM (Professor Gregory Woods)
Author:Korner, H (Professor Heinrich Korner)
ID Code:118222
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-07-06
Last Modified:2017-11-27
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