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The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection

journal contribution
posted on 2023-05-19, 07:03 authored by Li, X, Alan Lyons, Gregory WoodsGregory Woods, Heinrich KornerHeinrich Korner
During an immune response inflammatory macrophages with their wide variety of effector mechanisms including the expression of inducible nitric oxide synthase play an important part in the defense against invading pathogens. The inflammatory phenotype requires the presence of TNF which suppresses alternative activation. In the bacterial Listeria monocytogenes infection model inflammatory macrophages are crucial for protection. After infection, TNF-deficient hosts have a similar number of splenic macrophages but die rapidly. A more detailed analysis of these cells showed that while inducible nitric oxide synthase is expressed at a comparable level TNF-deficient macrophages show an increased expression of Arginase 1.

History

Publication title

Immunobiology

Volume

222

Issue

8-9

Pagination

913-917

ISSN

0171-2985

Department/School

Menzies Institute for Medical Research

Publisher

Urban & Fischer Verlag

Place of publication

Branch Office Jena, P O Box 100537, Jena, Germany, D-07705

Rights statement

© 2017 Elsevier GmbH. All rights reserved.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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