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The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection


Li, X and Lyons, AB and Woods, GM and Korner, H, The absence of TNF permits myeloid Arginase 1 expression in experimental L. monocytogenes infection, Immunobiology, 222, (8-9) pp. 913-917. ISSN 0171-2985 (2017) [Refereed Article]

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2017 Elsevier GmbH. All rights reserved.

DOI: doi:10.1016/j.imbio.2017.05.012


During an immune response inflammatory macrophages with their wide variety of effector mechanisms including the expression of inducible nitric oxide synthase play an important part in the defense against invading pathogens. The inflammatory phenotype requires the presence of TNF which suppresses alternative activation. In the bacterial Listeria monocytogenes infection model inflammatory macrophages are crucial for protection. After infection, TNF-deficient hosts have a similar number of splenic macrophages but die rapidly. A more detailed analysis of these cells showed that while inducible nitric oxide synthase is expressed at a comparable level TNF-deficient macrophages show an increased expression of Arginase 1.

Item Details

Item Type:Refereed Article
Keywords:macrophages, tumor necrosis factor, cell differentiation, Listeria monocytogenes
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Li, X (Ms Amy Li)
UTAS Author:Lyons, AB (Associate Professor Bruce Lyons)
UTAS Author:Woods, GM (Professor Gregory Woods)
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:118222
Year Published:2017
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-07-06
Last Modified:2018-06-06

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