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Microfluidic Device for Studying Traumatic Brain Injury


Yap, YC and Dickson, TC and King, AE and Breadmore, MC and Guijt, RM, Microfluidic Device for Studying Traumatic Brain Injury, Stem Cell Technologies in Neuroscience, Springer Science+Business Media LLC, AK Srivastava, EY Snyder, YD Teng (ed), New York, United States, pp. 145-156. ISBN 9781493970223 (2017) [Research Book Chapter]

Copyright Statement

Copyright 2017 Springer Science+Business Media LLC

DOI: doi:10.1007/978-1-4939-7024-7_10


Throughout the world, traumatic brain injury (TBI), for example, as a result of motor vehicle accident, is a major cause of mortality and lifelong disability in children and young adults. Studies show that axonal pathology and degeneration can cause significant functional impairment and can precede, and sometimes cause, neuronal death in several neurological disorders including TBI, creating a compelling need to understand the mechanisms of axon degeneration. Microfluidic devices that allow manipulation of fluids in channels with typical dimensions of tens to hundreds of micrometers have emerged as a powerful platform for such studies due to their ability to isolate and direct the growth of axons. Here, we describe a new microfluidic platform that can be used to study TBI by applying very mild (0.5%) and mild (5%) stretch injury to individual cortical axons through the incorporation of microfluidic valve technology into a compartmented microfluidic-culturing device. This device is unique due to its ability to study the neuronal response to axonal stretch injury in a fluidically isolated microenvironment.

Item Details

Item Type:Research Book Chapter
Keywords:microfluidic, stretch injury, traumatic brain injury, quake valve, primary cell culture
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Yap, YC (Dr Yiing Yap)
UTAS Author:Dickson, TC (Professor Tracey Dickson)
UTAS Author:King, AE (Professor Anna King)
UTAS Author:Breadmore, MC (Professor Michael Breadmore)
UTAS Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:118188
Year Published:2017
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2017-07-06
Last Modified:2018-12-14

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