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Chapter 10. Microfluidic Device for Studying Traumatic Brain Injury

Citation

Yap, YC and Dickson, TC and King, AE and Breadmore, MC and Guijt, RM, Chapter 10. Microfluidic Device for Studying Traumatic Brain Injury, Stem Cell Technologies in Neuroscience, Springer Science+Business Media LLC, AK Srivastava, EY Snyder, YD Teng (ed), New York, United States, pp. 145-156. ISBN 9781493970223 (2017) [Research Book Chapter]

Copyright Statement

Copyright 2017 Springer Science+Business Media LLC

DOI: doi:10.1007/978-1-4939-7024-7_10

Abstract

Throughout the world, traumatic brain injury (TBI), for example, as a result of motor vehicle accident, is a major cause of mortality and lifelong disability in children and young adults. Studies show that axonal pathology and degeneration can cause significant functional impairment and can precede, and sometimes cause, neuronal death in several neurological disorders including TBI, creating a compelling need to understand the mechanisms of axon degeneration. Microfluidic devices that allow manipulation of fluids in channels with typical dimensions of tens to hundreds of micrometers have emerged as a powerful platform for such studies due to their ability to isolate and direct the growth of axons. Here, we describe a new microfluidic platform that can be used to study TBI by applying very mild (0.5%) and mild (5%) stretch injury to individual cortical axons through the incorporation of microfluidic valve technology into a compartmented microfluidic-culturing device. This device is unique due to its ability to study the neuronal response to axonal stretch injury in a fluidically isolated microenvironment.

Item Details

Item Type:Research Book Chapter
Keywords:microfluidic stretch injury, traumatic brain injury, quake valve, primary cell culture
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Yap, YC (Dr Yiing Yap)
Author:Dickson, TC (Professor Tracey Dickson)
Author:King, AE (Associate Professor Anna King)
Author:Breadmore, MC (Professor Michael Breadmore)
Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:118188
Year Published:2017
Deposited By:Chemistry
Deposited On:2017-07-06
Last Modified:2017-12-13
Downloads:0

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