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Microfluidic model for mild traumatic brain injury

conference contribution
posted on 2023-05-23, 18:42 authored by Ying YapYing Yap, Tracey DicksonTracey Dickson, Anna KingAnna King, Michael BreadmoreMichael Breadmore, Rosanne Guijt
We have developed novel device where a localised axonal stretch injury is achieved by the integration of a pressure-flexible valve in the axon compartment of a fluidically isolated neuron culture device. We found that stretch injury resulted in the formation of smaller growth cones, significantly higher number of collapsed growth cones and different cytoskeletal profile compared to the growth cones in control, uninjured cultures. These results suggest that stretch injury to a very localized region of the cortical axon is able to trigger a degenerative response that is characterized by growth cone collapse and significant abnormal cytoskeletal rearrangement.

History

Publication title

Proceedings, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Editors

SC Jacobson, JP Kutter

Pagination

989-992

ISBN

978-0-9798064-7-6

Department/School

School of Natural Sciences

Publisher

Chemical and Biological Microsystems Society

Place of publication

San Diego, Califonia, United States

Event title

MicroTAS 2014: The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Event Venue

San Antonio, Texas, United States

Date of Event (Start Date)

2014-10-26

Date of Event (End Date)

2014-10-30

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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