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Microfluidic model for mild traumatic brain injury

Citation

Yap, YC and Dickson, TC and King, AE and Breadmore, MC and Guijt, RM, Microfluidic model for mild traumatic brain injury, Proceedings, The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 26-30 October 2014, San Antonio, Texas, United States, pp. 989-992. ISBN 978-0-9798064-7-6 (2014) [Non Refereed Conference Paper]


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Abstract

We have developed novel device where a localised axonal stretch injury is achieved by the integration of a pressure-flexible valve in the axon compartment of a fluidically isolated neuron culture device. We found that stretch injury resulted in the formation of smaller growth cones, significantly higher number of collapsed growth cones and different cytoskeletal profile compared to the growth cones in control, uninjured cultures. These results suggest that stretch injury to a very localized region of the cortical axon is able to trigger a degenerative response that is characterized by growth cone collapse and significant abnormal cytoskeletal rearrangement.

Item Details

Item Type:Non Refereed Conference Paper
Keywords:growth cones, microfluidic device, mild traumatic brain injury, cytoskeletal
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Cellular Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Yap, YC (Dr Yiing Yap)
Author:Dickson, TC (Associate Professor Tracey Dickson)
Author:King, AE (Associate Professor Anna King)
Author:Breadmore, MC (Professor Michael Breadmore)
Author:Guijt, RM (Dr Rosanne Guijt)
ID Code:118180
Year Published:2014
Deposited By:Chemistry
Deposited On:2017-07-06
Last Modified:2017-07-06
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