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Microfluidic model for mild traumatic brain injury
conference contribution
posted on 2023-05-23, 18:42 authored by Ying YapYing Yap, Tracey DicksonTracey Dickson, Anna KingAnna King, Michael BreadmoreMichael Breadmore, Rosanne GuijtWe have developed novel device where a localised axonal stretch injury is achieved by the integration of a pressure-flexible valve in the axon compartment of a fluidically isolated neuron culture device. We found that stretch injury resulted in the formation of smaller growth cones, significantly higher number of collapsed growth cones and different cytoskeletal profile compared to the growth cones in control, uninjured cultures. These results suggest that stretch injury to a very localized region of the cortical axon is able to trigger a degenerative response that is characterized by growth cone collapse and significant abnormal cytoskeletal rearrangement.
History
Publication title
Proceedings, The 18th International Conference on Miniaturized Systems for Chemistry and Life SciencesEditors
SC Jacobson, JP KutterPagination
989-992ISBN
978-0-9798064-7-6Department/School
School of Natural SciencesPublisher
Chemical and Biological Microsystems SocietyPlace of publication
San Diego, Califonia, United StatesEvent title
MicroTAS 2014: The 18th International Conference on Miniaturized Systems for Chemistry and Life SciencesEvent Venue
San Antonio, Texas, United StatesDate of Event (Start Date)
2014-10-26Date of Event (End Date)
2014-10-30Repository Status
- Restricted