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One-step fabrication of a microfluidic device with an integrated membrane and embedded reagents by multimaterial 3D printing


Li, F and Smejkal, P and Macdonald, NP and Guijt, RM and Breadmore, MC, One-step fabrication of a microfluidic device with an integrated membrane and embedded reagents by multimaterial 3D printing, Analytical Chemistry, 89, (8) pp. 4701-4707. ISSN 0003-2700 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 American Chemical Society

DOI: doi:10.1021/acs.analchem.7b00409


One of the largest impediments in the development of microfluidic-based smart sensing systems is the manufacturability of integrated, complex devices. Here we propose multimaterial 3D printing for the fabrication of such devices in a single step. A microfluidic device containing an integrated porous membrane and embedded liquid reagents was made by 3D printing and applied for the analysis of nitrate in soil. The manufacture of the integrated, sealed device was realized as a single print within 30 min. The body of the device was printed in transparent acrylonitrile butadiene styrene (ABS) and contained a 400 μm wide structure printed from a commercially available composite filament. The composite filament can be turned into a porous material through dissolution of a water-soluble material. Liquid reagents were integrated by briefly pausing the printing before resuming for sealing the device. The devices were evaluated by the determination of nitrate in a soil slurry containing zinc particles for the reduction of nitrate to nitrite using the Griess reagent. Using a consumer digital camera, the linear range of the detector response ranged from 0 to 60 ppm, covering the normal range of nitrate in soil. To ensure that the sealing of the reagent chamber is maintained, aqueous reagents should be avoided. When using the nonaqueous reagent, the multimaterial device containing the Griess reagent could be stored for over 4 days but increased the detection range to 100-500 ppm. Multimaterial 3D printing is a potentially new approach for the manufacture of microfluidic devices with multiple integrated functional components.

Item Details

Item Type:Refereed Article
Keywords:one-step fabrication, microfluidic device, integrated membrane, embedded reagents, 3D printing
Research Division:Engineering
Research Group:Manufacturing engineering
Research Field:Microtechnology
Objective Division:Manufacturing
Objective Group:Instrumentation
Objective Field:Scientific instruments
UTAS Author:Li, F (Mr Feng Li)
UTAS Author:Smejkal, P (Dr Petr Smejkal)
UTAS Author:Macdonald, NP (Dr Niall Macdonald)
UTAS Author:Guijt, RM (Dr Rosanne Guijt)
UTAS Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:118136
Year Published:2017
Web of Science® Times Cited:86
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2017-07-05
Last Modified:2018-03-27

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