Kornaczewski Jackson, ER and Pointon, OP and Bohmer, R and Brugess, JR, Utility of FDG-PET imaging for risk stratification of pancreatic neuroendocrine tumors in MEN1, Journal of Clinical Endocrinology and Metabolism, 102, (6) pp. 1926-1933. ISSN 0021-972X (2017) [Refereed Article]
Copyright 2017 Endocrine Society
Context: Patients with multiple endocrine neoplasia type 1 (MEN1) are at high risk of malignant pancreatic neuroendocrine tumors (pNETs). Structural imaging is typically used to screen for pNETs but is suboptimal for stratifying malignant potential.
Objective: To determine the utility of fluorodeoxyglucose (18F) positron emission tomography/computed tomography (18F-FDG PET/CT) for predicting the malignant potential of pNETs in MEN1.
Design: Retrospective observational study.
Setting: Tertiary referral hospital.
Patients: Forty-nine adult patients with MEN1 carrying a common MEN1 mutation who underwent 18F-FDG PET/CT for MEN1 surveillance between 1 January 2010 and 30 September 2016.
Interventions: Structural and functional imaging (magnetic resonance imaging, CT, ultrasonography, and 18F-FDG PET/CT) and surgical histopathology.
Main Outcome Measures: pNET size, behavior, and histopathology.
|Item Type:||Refereed Article|
|Keywords:||FDG-PET, pancreas, neuroendocrine tumours, MEN 1|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Endocrine Organs and Diseases (excl. Diabetes)|
|Author:||Brugess, JR (Professor John Burgess)|
|Web of Science® Times Cited:||3|
|Deposited By:||Medicine (Discipline)|
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