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Utility of FDG-PET imaging for risk stratification of pancreatic neuroendocrine tumors in MEN1

Citation

Kornaczewski Jackson, ER and Pointon, OP and Bohmer, R and Brugess, JR, Utility of FDG-PET imaging for risk stratification of pancreatic neuroendocrine tumors in MEN1, Journal of Clinical Endocrinology and Metabolism, 102, (6) pp. 1926-1933. ISSN 0021-972X (2017) [Refereed Article]


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Copyright Statement

Copyright 2017 Endocrine Society

DOI: doi:10.1210/jc.2016-3865

Abstract

Context: Patients with multiple endocrine neoplasia type 1 (MEN1) are at high risk of malignant pancreatic neuroendocrine tumors (pNETs). Structural imaging is typically used to screen for pNETs but is suboptimal for stratifying malignant potential.

Objective: To determine the utility of fluorodeoxyglucose (18F) positron emission tomography/computed tomography (18F-FDG PET/CT) for predicting the malignant potential of pNETs in MEN1.

Design: Retrospective observational study.

Setting: Tertiary referral hospital.

Patients: Forty-nine adult patients with MEN1 carrying a common MEN1 mutation who underwent 18F-FDG PET/CT for MEN1 surveillance between 1 January 2010 and 30 September 2016.

Interventions: Structural and functional imaging (magnetic resonance imaging, CT, ultrasonography, and 18F-FDG PET/CT) and surgical histopathology.

Main Outcome Measures: pNET size, behavior, and histopathology.

Item Details

Item Type:Refereed Article
Keywords:FDG-PET, pancreas, neuroendocrine tumours, MEN 1
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Endocrinology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Endocrine Organs and Diseases (excl. Diabetes)
Author:Brugess, JR (Professor John Burgess)
ID Code:118092
Year Published:2017
Web of Science® Times Cited:3
Deposited By:Medicine (Discipline)
Deposited On:2017-07-04
Last Modified:2017-12-04
Downloads:0

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