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Inappropriate prescribing in chronic kidney disease: A systematic review of prevalence, associated clinical outcomes and impact of interventions


Tesfaye, WH and Castelino, RL and Wimmer, BC and Zaidi, STR, Inappropriate prescribing in chronic kidney disease: A systematic review of prevalence, associated clinical outcomes and impact of interventions, International Journal of Clinical Practice, 71, (7) Article e12960. ISSN 1368-5031 (2017) [Refereed Article]

Copyright Statement

2017 John Wiley & Sons Ltd

DOI: doi:10.1111/ijcp.12960


Introduction: Adjusting doses of renally cleared medications and/or avoidance of nephrotoxic medications are standard clinical practices in chronic kidney disease (CKD), albeit the prevalence of inappropriate prescribing (IP) in these patients remains high. Therefore, this work sought to systematically review the prevalence of IP and compare the relative effectiveness of available interventions in reducing IP in CKD.

Methods: Studies were identified searching PubMed/Medline, EMBASE, Cochrane Library, IPA, Web of Science, Ovid/Medline, CINAHL, and PsychINFO databases. Studies defining CKD based on laboratory markers and quantifying prevalence of IP were included.

Results: Forty-nine studies from 23 countries met the inclusion criteria. An IP prevalence of 9.4%-81.1% and 13%-80.50% was reported in hospital and ambulatory settings, respectively; whereas, in long-term care facilities the prevalence ranged between 16% and 37.9%. Unsurprisingly, IP was associated with adverse drug events like increased hospital stay (Mean [SD] of 4.5 [4.8] vs 4.3 [4.5]) and high risk of mortality [40%]. Twenty-one studies reported the impact of interventions on IP; manual and computerised alerts were the main forms of interventions (n=19). The most significant reduction in IP was observed when physicians received immediate concurrent feedback from a clinical pharmacist (P<.001). Polypharmacy, comorbidities, and age were identified as predictors of IP.

Conclusion: IP has led to poor patient outcomes. Although pharmacist-based and computer-aided approaches have shown promising results, there is still room for improvement. Future studies should focus on developing a multifaceted intervention to address the widespread prevalence of IP and associated clinical outcomes in CKD patients.

Item Details

Item Type:Refereed Article
Keywords:systematic review, chronic kidney disease, inappropriate prescribing, interventions
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Tesfaye, WH (Mr Wubshet Tesfaye)
UTAS Author:Castelino, RL (Dr Ronald Castelino)
UTAS Author:Wimmer, BC (Dr Barbara Wimmer)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
ID Code:118040
Year Published:2017
Web of Science® Times Cited:40
Deposited By:Pharmacy
Deposited On:2017-07-03
Last Modified:2018-07-26

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