eCite Digital Repository

Vitamin D status and calcium intake in systemic inflammation, insulin resistance and the metabolic syndrome: An update on current evidence


Soares, MJ and Pannu, PK and Calton, EK and Reid, CM and Hills, AP, Vitamin D status and calcium intake in systemic inflammation, insulin resistance and the metabolic syndrome: An update on current evidence, Trends in Food Science and Technology, 62 pp. 79-90. ISSN 0924-2244 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 Elsevier Ltd.

DOI: doi:10.1016/j.tifs.2017.01.009


Background: Insufficient vitamin D status and inadequate intakes of calcium are a global concern and appear to be inversely linked to the global explosion in prevalence of the metabolic syndrome (MetS).

Scope and approach: This review provides an update of the current evidence on causal linkages between these nutrients and MetS. We adopted a simplified model that explored the effects of vitamin D and calcium on systemic inflammation and insulin resistance (IR), as initial derangements in the progression to MetS. We selected systematic reviews (SR) and meta-analyses (MA) of randomized controlled trials (RCTs) or large scale observational studies to better understand the evidence base in the area.

Key findings and conclusions: Observational data provided the best evidence for an inverse association between vitamin D status and presence of MetS. There was no convincing evidence from RCTs, except when participants with impaired glucose tolerance were studied. The influence of dietary calcium on systemic inflammation, IR and MetS has been inadequately studied to allow a firm conclusion. However, cellular and molecular evidence support a role for intra-cellular calcium in related disease states. Future long-term RCTs in adequately sampled participant groups are needed. Central to uncovering such extra-skeletal effects is the endpoint of interest, the selection of the study population, the potential of prior genotyping, consensus on ‘optimal’ vitamin D status, and the duration required of future trials. The concomitant study of mechanistic pathways in such trials could uncover potential targets for functional food development and drug therapy.

Item Details

Item Type:Refereed Article
Keywords:vitamin D, calcium, inflammation, insulin resistance, metabolic syndrome, systematic review
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutritional science
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Hills, AP (Professor Andrew Hills)
ID Code:117761
Year Published:2017
Web of Science® Times Cited:6
Deposited By:Health Sciences
Deposited On:2017-06-27
Last Modified:2018-09-26

Repository Staff Only: item control page