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Temporally specific miRNA expression patterns in the dorsal and ventral striatum of addiction-prone rats


Quinn, RK and James, MH and Hawkins, GE and Brown, AL and Heathcote, A and Smith, DW and Cairns, MJ and Dayas, CV, Temporally specific miRNA expression patterns in the dorsal and ventral striatum of addiction-prone rats, Addiction Biology, 23, (2) pp. 631-642. ISSN 1369-1600 (2018) [Refereed Article]

Copyright Statement

© 2017 Commonwealth of Australia

DOI: doi:10.1111/adb.12520


MicroRNAs (miRNAs) within the ventral and dorsal striatum have been shown to regulate addiction-relevant behaviours. However, it is unclear how cocaine experience alone can alter the expression of addiction-relevant miRNAs within striatal subregions. Further, it is not known whether differential expression of miRNAs in the striatum contributes to individual differences in addiction vulnerability. We first examined the effect of cocaine self-administration on the expression of miR-101b, miR-137, miR-212 and miR-132 in nucleus accumbens core and nucleus accumbens shell (NAcSh), as well as dorsomedial striatum and dorsolateral striatum (DLS). We then examined the expression of these same miRNAs in striatal subregions of animals identified as being ‘addiction-prone’, either immediately following self-administration training or following extinction and relapse testing. Cocaine self-administration was associated with changes in miRNA expression in a regionally discrete manner within the striatum, with the most marked changes occurring in the nucleus accumbens core. When we examined the miRNA profile of addiction-prone rats following self-administration, we observed increased levels of miR-212 in the dorsomedial striatum. After extinction and relapse testing, addiction-prone rats showed significant increases in the expression of miR-101b, miR-137, miR-212 and miR-132 in NAcSh, and miR-137 in the DLS. This study identifies temporally specific changes in miRNA expression consistent with the engagement of distinct striatal subregions across the course of the addiction cycle. Increased dysregulation of miRNA expression in NAcSh and DLS at late stages of the addiction cycle may underlie habitual drug seeking, and may therefore aid in the identification of targets designed to treat addiction.

Item Details

Item Type:Refereed Article
Keywords:cocaine, individual differences, miRNA, reinstatement, relapse, self-administration, striatum
Research Division:Psychology
Research Group:Biological psychology
Research Field:Behavioural neuroscience
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in psychology
UTAS Author:Heathcote, A (Professor Andrew Heathcote)
ID Code:117616
Year Published:2018 (online first 2017)
Web of Science® Times Cited:21
Deposited By:Psychology
Deposited On:2017-06-21
Last Modified:2018-07-25

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