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Recent rodent models for Alzheimer's disease: Clinical implications and basic research

Citation

Braidy, N and Munoz, P and Palacios, AG and Castellano-Gonzalez, G and Inestrosa, NC and Chung, RS and Sachdev, P and Guillemin, GJ, Recent rodent models for Alzheimer's disease: Clinical implications and basic research, Journal of Neural Transmission, 119, (2) pp. 173-195. ISSN 0300-9564 (2012) [Refereed Article]

Copyright Statement

Copyright Springer-Verlag 2011

DOI: doi:10.1007/s00702-011-0731-5

Abstract

Alzheimer’s disease (AD) is the most common origin of dementia in the elderly. Although the cause of AD remains unknown, several factors have been identified that appear to play a critical role in the development of this debilitating disorder. In particular, amyloid precursor protein (APP), tau hyperphosphorylation, and the secretase enzymes, have become the focal point of recent research. Over the last two decades, several transgenic and non-transgenic animal models have been developed to elucidate the mechanistic aspects of AD and to validate potential therapeutic targets. Transgenic rodent models over-expressing human β-amyloid precursor protein (β-APP) and mutant forms of tau have become precious tools to study and understand the pathogenesis of AD at the molecular, cellular and behavioural levels, and to test new therapeutic agents. Nevertheless, none of the transgenic models of AD recapitulate fully all of the pathological features of the disease. Octodon degu, a South American rodent has been recently found to spontaneously develop neuropathological signs of AD in old age. This review aims to address the limitations and clinical relevance of transgenic rodent models in AD, and to highlight the potential for O. degu as a natural model for the study of AD neuropathology.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer’s disease, animal models, Octodon degu, amyloid-b, tau phosphorylation, transgenic models
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Chung, RS (Associate Professor Roger Chung)
ID Code:117578
Year Published:2012
Web of Science® Times Cited:55
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-06-20
Last Modified:2017-07-26
Downloads:0

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