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Does the principle of minimum work apply at the carotid bifurcation: a retrospective cohort study


Beare, RJ and Das, G and Ren, M and Chong, W and Sinnott, MD and Hilton, JE and Srikanth, V and Phan, TG, Does the principle of minimum work apply at the carotid bifurcation: a retrospective cohort study, BMC Medical Imaging, 11 Article 17. ISSN 1471-2342 (2011) [Refereed Article]


Copyright Statement

Copyright 2011 Beare et al. Licensed under Creative Commons Attribution 2.0 Generic (CC BY 2.0)

DOI: doi:10.1186/1471-2342-11-17


BACKGROUND: There is recent interest in the role of carotid bifurcation anatomy, geometry and hemodynamic factors in the pathogenesis of carotid artery atherosclerosis. Certain anatomical and geometric configurations at the carotid bifurcation have been linked to disturbed flow. It has been proposed that vascular dimensions are selected to minimize energy required to maintain blood flow, and that this occurs when an exponent of 3 relates the radii of parent and daughter arteries. We evaluate whether the dimensions of bifurcation of the extracranial carotid artery follow this principle of minimum work.

METHODS: This study involved subjects who had computed tomographic angiography (CTA) at our institution between 2006 and 2007. Radii of the common, internal and external carotid arteries were determined. The exponent was determined for individual bifurcations using numerical methods and for the sample using nonlinear regression.

RESULTS: Mean age for 45 participants was 56.9 16.5 years with 26 males. Prevalence of vascular risk factors was: hypertension--48%, smoking--23%, diabetes--16.7%, hyperlipidemia--51%, ischemic heart disease--18.7%.The value of the exponent ranged from 1.3 to 1.6, depending on estimation methodology.

CONCLUSIONS: The principle of minimum work (defined by an exponent of 3) may not apply at the carotid bifurcation. Additional factors may play a role in the relationship between the radii of the parent and daughter vessels.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Radiology and organ imaging
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Srikanth, V (Dr Velandai Srikanth)
ID Code:117455
Year Published:2011
Web of Science® Times Cited:10
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-06-15
Last Modified:2017-11-01
Downloads:114 View Download Statistics

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