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Battery-powered nonaqueous microchip electrophoresis system for rapid analysis of tamoxifen and its metabolites in human plasma
Citation
See, HH and Thang, LY and Woodhouse, O, Battery-powered nonaqueous microchip electrophoresis system for rapid analysis of tamoxifen and its metabolites in human plasma, Proceedings of the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015), 25-29 October, Gyeongyu, Korea, pp. 1981-1983. ISBN 978-1-5108-1787-6 (2015) [Conference Extract]
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Copyright Statement
Copyright 2015 Chemical and Biological Microsystems Society
Official URL: http://www.cegss.ptchem.pl/microtas-2015-19th-inte...
Abstract
A novel quantification method for anti-estrogen drugs in human plasma on a fully functional, battery-operated nonaqueous microchip electrophoresis (MCE) system coupled with contactless conductivity detection (C4D) was developed. The entire system was powered by a 12 V DC output NiMH rechargeable battery pack. A baseline separation for the detection of tamoxifen and its metabolites was achieved in 1.3 minutes. The results obtained are comparable to the conventional NACE method, which in assay sensitivity corresponded to a limit of detection (LOD) of 45 ng/mL and acceptable RSD range of 2.5-3.4%.
Item Details
Item Type: | Conference Extract |
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Keywords: | nonaqueous microchip electrophoresis, contactless conductivity detection, Tamoxifen |
Research Division: | Chemical Sciences |
Research Group: | Analytical chemistry |
Research Field: | Separation science |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | See, HH (Dr Hong Heng See) |
UTAS Author: | Thang, LY (Ms Lee Yien Thang) |
ID Code: | 117353 |
Year Published: | 2015 |
Deposited By: | Austn Centre for Research in Separation Science |
Deposited On: | 2017-06-08 |
Last Modified: | 2018-03-13 |
Downloads: | 0 |
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