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Battery-powered nonaqueous microchip electrophoresis system for rapid analysis of tamoxifen and its metabolites in human plasma

Citation

See, HH and Thang, LY and Woodhouse, O, Battery-powered nonaqueous microchip electrophoresis system for rapid analysis of tamoxifen and its metabolites in human plasma, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015) Proceedings, 25-29 October, Gyeongyu, Korea, pp. 1981-1983. ISBN 978-1-5108-1787-6 (2015) [Refereed Conference Paper]


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Copyright Statement

Copyright 2015 Chemical and Biological Microsystems Society

Official URL: http://www.cegss.ptchem.pl/microtas-2015-19th-inte...

Abstract

A novel quantification method for anti-estrogen drugs in human plasma on a fully functional, battery-operated nonaqueous microchip electrophoresis (MCE) system coupled with contactless conductivity detection (C4D) was developed. The entire system was powered by a 12 V DC output NiMH rechargeable battery pack. A baseline separation for the detection of tamoxifen and its metabolites was achieved in 1.3 minutes. The results obtained are comparable to the conventional NACE method, which in assay sensitivity corresponded to a limit of detection (LOD) of 45 ng/mL and acceptable RSD range of 2.5-3.4%.

Item Details

Item Type:Refereed Conference Paper
Keywords:nonaqueous microchip electrophoresis, contactless conductivity detection, Tamoxifen
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Separation Science
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:See, HH (Dr Hong Heng See)
Author:Thang, LY (Ms Lee Yien Thang)
ID Code:117353
Year Published:2015
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2017-06-08
Last Modified:2017-07-18
Downloads:0

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