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Association between the serotonin transporter gene polymorphism and verbal learning in older adults is moderated by gender
Citation
Imlach, A-R and Ward, DD and Vickers, JC and Summers, MJ and Felmingham, KL, Association between the serotonin transporter gene polymorphism and verbal learning in older adults is moderated by gender, Translational Psychiatry, 7 pp. 1-7. ISSN 2158-3188 (2017) [Refereed Article]
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Copyright Statement
Copyright 2017 The Author(s). Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract
The S allele of the functional 5-HTTLPR polymorphism has previously been associated with reductions in memory function. Given
the change in function of the serotonergic system in older adults, and the functional consequences of memory decline in this age
group, further investigation into the impact of 5-HTTLPR in healthy older adults is required. This investigation examined the effect
of 5-HTTLPR variants (S carriers versus L/L homozygotes) on verbal and visual episodic memory in 438 healthy older adults
participating in the Tasmanian Healthy Brain Project (age range 50–79 years, M= 60.35, s.d. = 6.75). Direct effects of HTTLPR on
memory processes, in addition to indirect effects through interaction with age and gender, were assessed. Although no direct
effects of 5-HTTLPR on memory processes were identified, our results indicated that gender significantly moderated the impact that
5-HTTLPR variants exerted on the relationship between age and verbal episodic memory function as assessed by the Rey Auditory
Verbal Learning Test. No significant direct or indirect effects were identified in relation to visual memory performance. Overall, this
investigation found evidence to suggest that 5-HTTLPR genotype affects the association of age and verbal episodic memory for
males and females differently, with the predicted negative effect of S carriage present in males but not females. Such findings
indicate a gender-dependent role for 5-HTTLPR in the verbal episodic memory system of healthy older adults.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | gender, serotonin, transporter, cognitive function, moderation, ageing |
| Research Division: | Psychology and Cognitive Sciences |
| Research Group: | Psychology |
| Research Field: | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Nervous System and Disorders |
| Author: | Imlach, A-R (Miss Abbie-Rose Imlach) |
| Author: | Ward, DD (Mr David Ward) |
| Author: | Vickers, JC (Professor James Vickers) |
| Author: | Summers, MJ (Dr Mathew Summers) |
| Author: | Felmingham, KL (Professor Kim Felmingham) |
| ID Code: | 117340 |
| Year Published: | 2017 |
| Deposited By: | Wicking Dementia Research and Education Centre |
| Deposited On: | 2017-06-07 |
| Last Modified: | 2017-08-17 |
| Downloads: | 17 View Download Statistics |
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