eCite Digital Repository

Longitudinal changes in excess pressure independently predict declining renal function among healthy individuals - A pilot study

Citation

Climie, RED and Picone, DS and Sharman, JE, Longitudinal changes in excess pressure independently predict declining renal function among healthy individuals - A pilot study, American Journal of Hypertension, 30, (8) pp. 772-775. ISSN 0895-7061 (2017) [Refereed Article]


Preview
PDF (final published version)
Pending copyright assessment - Request a copy
138Kb
  

Copyright Statement

Copyright 2017 American Journal of Hypertension, Ltd.

DOI: doi:10.1093/ajh/hpx091

Abstract

BACKGROUND: Aortic reservoir function independently predicts end-organ damage in cross-sectional analyses. However, longitudinal associations are more important regarding causation, but this has never been examined at rest or in response to light-moderate intensity exercise. The aim of this study was to determine the association between the change in aortic reservoir characteristics, in particular excess pressure integral (Pexcess) at rest and in response to exercise and the change in kidney function among healthy individuals followed over time.

METHODS: Aortic reservoir function (Pexcess and reservoir pressure), aortic stiffness, brachial and central blood pressure (BP), and renal function (estimated glomerular filtration rate [eGFR]) were recorded among 33 healthy individuals (57 9 years; 55% male) at baseline and after an average 3.0 0.3 years.

RESULTS: Over the follow up period, there was a significant increase in resting brachial BP, central BP, Pexcess, and aortic stiffness (P < 0.05 all). The change over time in resting Pexcess (but not aortic stiffness) was significantly related to the change in eGFR (r = -0.38, P = 0.038) and remained independent of age at follow up, change in 24-hour ambulatory systolic BP and body mass index (β = -0.0300, P = 0.043). There was no association between the change in aortic pulse wave velocity and the change eGFR (P = 0.46) nor were there any associations with exercising hemodynamics.

CONCLUSIONS: Pexcess is independently associated with a decline in renal function among healthy people followed over 3 years. These novel findings indicate the need to determine the underlying physiological determinants of aortic reservoir function.

Item Details

Item Type:Refereed Article
Keywords:arterial stiffness, blood pressure, hypertension, reservoir characteristics
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Cardiology (incl. Cardiovascular Diseases)
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Climie, RED (Miss Rachel Climie)
Author:Picone, DS (Mr Dean Picone)
Author:Sharman, JE (Professor James Sharman)
ID Code:117300
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-06-07
Last Modified:2017-11-22
Downloads:0

Repository Staff Only: item control page