Climie, RED and Picone, DS and Sharman, JE, Longitudinal changes in excess pressure independently predict declining renal function among healthy individuals - A pilot study, American Journal of Hypertension, 30, (8) pp. 772-775. ISSN 0895-7061 (2017) [Refereed Article]
Copyright 2017 American Journal of Hypertension, Ltd.
Methods: Aortic reservoir function (Pexcess and reservoir pressure), aortic stiffness, brachial and central blood pressure (BP), and renal function (estimated glomerular filtration rate [eGFR]) were recorded among 33 healthy individuals (57 ± 9 years; 55% male) at baseline and after an average 3.0 ± 0.3 years.
Results: Over the follow up period, there was a significant increase in resting brachial BP, central BP, Pexcess, and aortic stiffness (P < 0.05 all). The change over time in resting Pexcess (but not aortic stiffness) was significantly related to the change in eGFR (r = -0.38, P = 0.038) and remained independent of age at follow up, change in 24-hour ambulatory systolic BP and body mass index (β = -0.0300, P = 0.043). There was no association between the change in aortic pulse wave velocity and the change eGFR (P = 0.46) nor were there any associations with exercising hemodynamics.
Conclusions: Pexcess is independently associated with a decline in renal function among healthy people followed over 3 years. These novel findings indicate the need to determine the underlying physiological determinants of aortic reservoir function.
|Item Type:||Refereed Article|
|Keywords:||arterial stiffness, blood pressure, hypertension, reservoir characteristics|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Climie, RED (Dr Rachel Climie)|
|UTAS Author:||Picone, DS (Dr Dean Picone)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|Deposited By:||Menzies Institute for Medical Research|
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