Dargaville, PA and Lavizzari, A and Padoin, P and Black, D and Zonneveld, E and Perkins, E and Sourial, M and Rajapaksa, AE and Davis, PG and Hooper, SB and Moss, TJM and Polglase, GR and Tingay, DG, An authentic animal model of the very preterm infant on nasal continuous positive airway pressure, Intensive Care Medicine Experimental, 3, (1) Article 13. ISSN 2197-425X (2015) [Refereed Article]
© 2015 Dargaville et al.; licensee Springer. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/
RESULTS: Ten preterm lambs were studied, at gestation 132 ± 1 days (mean ± SD) and birth weight 3.6 ± 0.45 kg. After stabilisation on NIPPV, transition to nasal CPAP was first attempted at 28 ± 11 min. There was transient respiratory acidosis, with gradual resolution as spontaneous respiratory activity increased. In the final hour, 79% ± 33% of time was spent on CPAP alone, with typical respiratory rates around 60 breaths per minute. PaCO2 at end-experiment was 58 ± 36 mmHg.
CONCLUSIONS: Non-intubated preterm lambs can be effectively transitioned to nasal CPAP soon after birth. This animal model will be valuable for further research.
|Item Type:||Refereed Article|
|Keywords:||Preterm lamb, Continuous positive airway pressure, Non-invasive positive pressure ventilation, Apnoea|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Paediatrics not elsewhere classified|
|Objective Group:||Specific population health (excl. Indigenous health)|
|Objective Field:||Neonatal and child health|
|UTAS Author:||Dargaville, PA (Professor Peter Dargaville)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||102 View Download Statistics|
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