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Utility of FDG-PET imaging in screening for succinate dehydrogenase B and D mutation-related lesions

Citation

Kornaczewski, ER and Pointon, OP and Burgess, JR, Utility of FDG-PET imaging in screening for succinate dehydrogenase B and D mutation-related lesions, Clinical Endocrinology, 85, (2) pp. 172-179. ISSN 0300-0664 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 John Wiley & Sons Ltd.

DOI: doi:10.1111/cen.13020

Abstract

Objective: Mutations of the genes encoding succinate dehydrogenase B and D (SDHB, SDHD) are associated with highly penetrant phenotypes, including paragangliomas and phaeochromocytomas. Patients with these mutations require lifelong surveillance; however, there is currently ambiguity regarding the optimal screening regimen. We sought to determine the utility of fluorodeoxyglucose (18F) positron emission tomography (18F-FDG PET) imaging, compared to other modalities for detecting SDHB and SDHD mutation-related lesions.

Design: A retrospective audit of patients with SDHB or SDHD mutation. Patients All adult patients with confirmed SDHB and SDHD mutations who underwent 18F-FDG PET/CT at our institution between 1 July 2011 and 30 May 2015.

Measurements: 18F-FDG PET/computed tomography (CT) performed during surveillance of patients with SDHB and SDHD mutations. Lesion numbers and locations detected by 18F-FDG PET were compared to those identified on the CT component, as well as other imaging modalities and histology when available.

Results: Thirty-one 18F-FDG PET/CT studies were completed on 22 patients. For SDHB (20 patients), there were five positive and 21 negative studies. There were no false-negative 18F-FDG PET studies. Positive 18F-FDG PET findings correlated with magnetic resonance imaging (MRI), CT and [68 Ga]-DOTA(0)- Tyr(3)-octreotate (68 Ga DOTATATE PET/CT) imaging with no missed lesions; the only potential false-positive result relating to nonspecific postoperative changes (sensitivity 1000%, speci- ficity 955%). For SDHD (two patients), lesions were detected on 18F-FDG PET and correlated with other imaging in three of five studies. Metastatic lesions were incompletely visualized on 18F-FDG PET but were detected on the noncontrast fusion CT.

Conclusions: 18F-FDG PET/CT is suitable for detecting SDHB and SDHD mutation-related lesions and may be considered effective for periodic surveillance of patients with these mutations.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Burgess, JR (Professor John Burgess)
ID Code:117086
Year Published:2016
Web of Science® Times Cited:5
Deposited By:Medicine (Discipline)
Deposited On:2017-05-31
Last Modified:2017-11-03
Downloads:0

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