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Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD

Citation

Soltani, A and Walters, EH and Reid, DW and Shukla, SD and Nowrin, K and Ward, C and Muller, HK and Sohal, SS, Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD, International Journal of COPD, 11, (1) pp. 2359-2367. ISSN 1178-2005 (2016) [Refereed Article]


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Copyright 2016 Soltani et al. Licensed under Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) https://creativecommons.org/licenses/by-nc/3.0/

DOI: doi:10.2147/COPD.S113176

Abstract

© 2016 Soltani et al.Background: This study assessed the effects of inhaled corticosteroid (ICS) on airway vascular remodeling in chronic obstructive pulmonary disease (COPD). Methods: Thirty-four subjects with mild-to-moderate COPD were randomly allocated 2:1 to ICS or placebo treatment in a double-blinded clinical trial over 6 months. Available tissue was compared before and after treatment for vessel density, and expression of VEGF, TGF-β1, and TGF-β1-related phosphorylated transcription factors p-SMAD 2/3. This clinical trial has been registered and allocated with the Australian New Zealand Clinical Trials Registry (ANZCTR) on 17/10/2012 with reference number ACTRN12612001111864. Results: There were no significant baseline differences between treatment groups. With ICS, vessels and angiogenic factors did not change in hypervascular reticular basement membrane, but in the hypovascular lamina propria (LP), vessels increased and this had a proportionate effect on lung air trapping. There was modest evidence for a reduction in LP vessels staining for VEGF with ICS treatment, but a marked and significant reduction in p-SMAD 2/3 expression. Conclusion: Six-month high-dose ICS treatment had little effect on hypervascularity or angiogenic growth factors in the reticular basement membrane in COPD, but normalized hypovascularity in the LP, and this was physiologically relevant, though accompanied by a paradoxical reduction in growth factor expression.

Item Details

Item Type:Refereed Article
Keywords:airway remodeling, bronchial biopsy, COPD, inhaled corticosteroid, vascular remodeling
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Soltani, A (Dr Amir Soltani Abhari)
Author:Walters, EH (Professor Haydn Walters)
Author:Reid, DW (Dr David Reid)
Author:Shukla, SD (Mr Shakti Shukla)
Author:Nowrin, K (Ms Kaosia Nowrin)
Author:Muller, HK (Professor Konrad Muller)
Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:117054
Year Published:2016
Web of Science® Times Cited:4
Deposited By:Medicine (Discipline)
Deposited On:2017-05-30
Last Modified:2017-11-03
Downloads:4 View Download Statistics

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