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Amino acid dosing in parenteral nutrition for very low birth weight preterm neonates: An outcome assessment


Kamarudin, NA and Manan, MM and Zulkifly, HH and Neoh, CF and Ali, SM and Ming, LC, Amino acid dosing in parenteral nutrition for very low birth weight preterm neonates: An outcome assessment, Asia Pacific Journal of Clinical Nutrition, 25, (1) pp. 53-61. ISSN 0964-7058 (2016) [Refereed Article]

Copyright Statement

Copyright 2016 Asia Pacific Journal of Clinical Nutrition

DOI: doi:10.6133/apjcn.2016.25.2.02


This study aimed to investigate the effects of parenteral nutrition (PN) administration of amino acids (AA) on physical changes among very low birth weight infants in a local hospital setting in Malaysia. A retrospective study was carried out at a hospital in Malaysia. Records of neonates prescribed PN in the neonatal unit in 2012 were screened for eligibility. A total of 199 premature neonates received PN support in the year 2012 and, of these, 100 fulfilled the inclusion criteria. The median value of AA intake on the first day of PN was 2.00 (< 28 weeks group); 1.00 (28-31 weeks group) and 0.75 (>31 weeks group). Neonates in the < 28 weeks group were more likely to receive AA at an earlier time and higher initial dose compared with the other age groups. The study also found that there was no statistically significant difference in the dose of AA on the first day of PN administration and that the significant variations in nutritional parameters among the subjects did not lead to differences in physical outcomes. This study identified that when PN is provided in the local hospital setting, it is likely that the current nutritional practices are inadequate to achieve the standard growth recommendations. Our findings call for a need to optimize AA and calorie intake since growth restriction is a morbidity which will affect the infants' growth and development. Current prescriptions for PN in this hospital need to be reviewed in order to improve patient outcomes.

Item Details

Item Type:Refereed Article
Keywords:birth weight, nutritional requirements, growth and development, nutritional support, nutritional therapy
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Ming, LC (Dr Long Ming)
ID Code:117037
Year Published:2016
Web of Science® Times Cited:2
Deposited By:Pharmacy
Deposited On:2017-05-29
Last Modified:2017-11-02

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