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Associations between vitamin D receptor gene polymorphisms and ankylosing spondylitis in Chinese Han population: a case-control study

Citation

Cai, G and Zhang, X and Xin, L and Wang, L and Wang, M and Yang, X and Li, X and Xia, Q and Xu, S and Ding, C and Pan, F, Associations between vitamin D receptor gene polymorphisms and ankylosing spondylitis in Chinese Han population: a case-control study, Osteoporosis International, 27, (7) pp. 2327-2333. ISSN 0937-941X (2016) [Refereed Article]

Copyright Statement

Copyright International Osteoporosis Foundation and National Osteoporosis Foundation 2016

DOI: doi:10.1007/s00198-016-3500-3

Abstract

We assessed whether the vitamin D receptor gene polymorphisms (FokI, BsmI, ApaI, and TaqI) were associated with ankylosing spondylitis (AS) in a Chinese Han population. The TaqI polymorphism G allele was a risk factor in AS susceptibility.

INTRODUCTION: Previous studies have found that serum vitamin D levels are declined in patients with AS. The present study aims to evaluate the role of vitamin D receptor (VDR) gene polymorphisms in AS susceptibility in a Chinese Han population.

METHODS: Four single nucleotide polymorphisms (SNPs) in the VDR gene (FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236)) were genotyped by the improved multiplex ligase detection reaction (iMLDR) method in 620 AS patients and 620 geographically and ethnically matched healthy controls. Haplotypes were constructed after linkage disequilibrium (LD) analysis.

RESULTS: Statistically significant difference was only found in the TaqI polymorphism between AS patients and controls. The TaqI polymorphism G allele was higher in AS group than that in controls (OR [95 % CI] = 1.624 [1.122-2.352], χ2 = 6.705, P = 0.006). Linkage disequilibrium has been detected in TaqI and BsmI polymorphisms (D' = 0.87, r2 = 0.70). Two novel haplotypes (H1: AC and H2: GT) were significantly associated with the risk of AS, and they play protective and risk roles in AS morbidity, respectively.

CONCLUSIONS: The VDR gene TaqI polymorphism G allele may be a risk factor in AS susceptibility.

Item Details

Item Type:Refereed Article
Keywords:Ankylosing spondylitis, Polymorphism, VDR, Vitamin D receptor gene
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Ding, C (Professor Chang-Hai Ding)
Author:Pan, F (Professor Faming Pan)
ID Code:116940
Year Published:2016
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-05-25
Last Modified:2017-11-01
Downloads:0

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