eCite Digital Repository
A systematic literature review of biomarker methods used to measure total flavonoid intake and intake of selected flavonoid subclasses
Citation
Kent, K and Charlton, K and Probst, Y and Guan, V, A systematic literature review of biomarker methods used to measure total flavonoid intake and intake of selected flavonoid subclasses, Dietitians Association of Australia for the 34th National Conference, 18-20 May 2017, Hobart, Tasmania (2017) [Conference Extract]
![]() | PDF (DAA_2017_A SYSTEMATIC LITERATURE REVIEW OF BIOMARKER METHODS USED TO MEASURE TOTAL FLAVONOID INTAKE AND INTAKE OF SELECTEd SUBCALSSES) Pending copyright assessment - Request a copy 319Kb |
Abstract
A clear understanding of the most appropriate biomarker to measure flavonoid intake is
required to inform clinical nutrition studies and epidemiological research. A systematic
literature review was conducted to evaluate literature that validated or applied a biomarker
method to measure dietary flavonoid intake in adult populations. A comprehensive
database and internet search was conducted, alongside hand searching of reference lists of
included studies. Potential studies (n=891) were assessed according to inclusion criteria,
leaving 17 final papers in the review, with 13 studies validating biomarkers of flavonoid
intake against both dietary assessment methods and intervention diets, and 4 applying
flavonoid biomarkers as a measure of flavonoid intake. Relevant information relating to the
biomarker, assessment method, biological sample, flavonoid sub-group, study design, and
the key methodological conclusions was extracted from the studies. There was lack of
homogeneity between the study designs however pooling of the correlations (r) in the
validation studies was possible. The 13 validation studies identified various biomarkers,
including parent flavonoids and phenolic acid metabolites measured in urine and
plasma. Pooled 'Sum of flavonoid' biomarkers were strongly correlated with total flavonoid
intake (r=0.58). The biomarker quercetin was strongly correlated with quercetin intake
(r=0.68) and kaempferol was moderately correlated with kaempferol intake (r=0.44). Four
case-control studies measured tea-related flavonoid biomarkers as a measure of tea intake.
While multiple biomarkers may correlate with some dietary assessment outcomes, overall
there is a lack of biomarker(s) that can accurately reflect dietary flavonoid intake and more
studies are needed to inform future clinical research.
Item Details
Item Type: | Conference Extract |
---|---|
Keywords: | flavonoid, biomarker, nutrition assessment |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Nutrition and dietetics |
Research Field: | Nutrition and dietetics not elsewhere classified |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Nutrition |
UTAS Author: | Kent, K (Dr Katherine Kent) |
ID Code: | 116805 |
Year Published: | 2017 |
Deposited By: | UTAS Centre for Rural Health |
Deposited On: | 2017-05-22 |
Last Modified: | 2017-06-09 |
Downloads: | 0 |
Repository Staff Only: item control page