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Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii)

Citation

Ujvari, B and Hamede, R and Peck, S and Pemberton, D and Jones, M and Belov, K and Madsen, T, Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii), Scientific Reports, 6 Article 25093. ISSN 2045-2322 (2016) [Refereed Article]


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DOI: doi:10.1038/srep25093

Abstract

Immunoglobulins such as IgG and IgM have been shown to induce anti-tumour cytotoxic activity. In the present study we therefore explore total serum IgG and IgM expression dynamics in 23 known-aged Tasmanian devils (Sarcophilus harrisii) of which 9 where affected by Devil Facial Tumour Disease (DFTD). DFTD is clonally transmissible cancer that has caused massive declines in devil numbers. Our analyses revealed that IgM and IgG expression levels as well as IgM/IgG ratios decreased with increasing devil age. Neither age, sex, IgM nor IgG expression levels affected devil DFTD status in our analyses. However, devils with increased IgM relative to IgG expression levels had significantly lower DFTD prevalence. Our results therefore suggest that IgM/IgG ratios may play an important role in determining devil susceptibility to DFTD. We consequently propose that our findings warrant further studies to elucidate the underpinning(s) of devil IgM/IgG ratios and DFTD status.

Item Details

Item Type:Refereed Article
Keywords:immunoglobin, cancer, Tasmanian devil, devil facial tumor disease
Research Division:Environmental Sciences
Research Group:Environmental Science and Management
Research Field:Conservation and Biodiversity
Objective Division:Environment
Objective Group:Flora, Fauna and Biodiversity
Objective Field:Flora, Fauna and Biodiversity at Regional or Larger Scales
Author:Hamede, R (Mr Rodrigo Hamede Ross)
Author:Jones, M (Associate Professor Menna Jones)
ID Code:116764
Year Published:2016
Deposited By:Zoology
Deposited On:2017-05-19
Last Modified:2017-05-19
Downloads:0

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