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Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii)
Citation
Ujvari, B and Hamede, R and Peck, S and Pemberton, D and Jones, M and Belov, K and Madsen, T, Immunoglubolin dynamics and cancer prevalence in Tasmanian devils (Sarcophilus harrisii), Scientific Reports, 6 Article 25093. ISSN 2045-2322 (2016) [Refereed Article]
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Copyright Statement
Copyright 2016 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Abstract
Immunoglobulins such as IgG and IgM have been shown to induce anti-tumour cytotoxic activity. In the present study we therefore explore total serum IgG and IgM expression dynamics in 23 known-aged Tasmanian devils (Sarcophilus harrisii) of which 9 where affected by Devil Facial Tumour Disease (DFTD). DFTD is clonally transmissible cancer that has caused massive declines in devil numbers. Our analyses revealed that IgM and IgG expression levels as well as IgM/IgG ratios decreased with increasing devil age. Neither age, sex, IgM nor IgG expression levels affected devil DFTD status in our analyses. However, devils with increased IgM relative to IgG expression levels had significantly lower DFTD prevalence. Our results therefore suggest that IgM/IgG ratios may play an important role in determining devil susceptibility to DFTD. We consequently propose that our findings warrant further studies to elucidate the underpinning(s) of devil IgM/IgG ratios and DFTD status.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | immunoglobin, cancer, Tasmanian devil, devil facial tumor disease |
| Research Division: | Environmental Sciences |
| Research Group: | Environmental management |
| Research Field: | Conservation and biodiversity |
| Objective Division: | Environmental Management |
| Objective Group: | Terrestrial systems and management |
| Objective Field: | Terrestrial biodiversity |
| UTAS Author: | Hamede, R (Dr Rodrigo Hamede Ross) |
| UTAS Author: | Jones, M (Professor Menna Jones) |
| ID Code: | 116764 |
| Year Published: | 2016 |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Zoology |
| Deposited On: | 2017-05-19 |
| Last Modified: | 2022-08-25 |
| Downloads: | 168 View Download Statistics |
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