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CCR6/CCL20 chemokine axis in human immunodeficiency virus immunity and pathogenesis

Citation

Lee, AYS and Korner, H, CCR6/CCL20 chemokine axis in human immunodeficiency virus immunity and pathogenesis, Journal of General Virology, 98, (3) pp. 338-344. ISSN 0022-1317 (2017) [Refereed Article]

Copyright Statement

Copyright 2017 The Authors

DOI: doi:10.1099/jgv.0.000691

Abstract

Recent studies in human immunodeficiency virus (HIV) have garnered interest for the role of CC chemokine receptor 6 (CCR6) and its known ligands, CC chemokine ligand 20 (CCL20) and human β-defensins, in viral entry, dissemination and antiviral immunity. Several studies have suggested that CCR6 may also act as a weak co-receptor of HIV entry, in addition to the canonical CXC chemokine receptor 4 (CXCR4) and CCR5. However, the pathogenic significance has yet to be demonstrated as the observations for preferential infection of CD4+CCR6+ over CD4+CCR6- T cells appear to be independent of CCR6 expression. This indicates means for preferential infection other than CCR6 co-receptor use. Attention has also turned to the inadvertent role of the CCR6/CCL20 axis in attracting key immune cells, including TH17 cells and dendritic cells, to sites of infection and propagating the virus to other sites of the body. This review article will summarize the latest evidence that the CCR6/CCL20 chemokine axis is playing an important role in HIV pathogenesis and immunity. Further work with in vivo studies is needed to establish the biological and, hence, therapeutic significance of these findings.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Lee, AYS (Dr Adrian Lee)
Author:Korner, H (Professor Heinrich Korner)
ID Code:116527
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-05-11
Last Modified:2017-09-22
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