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Baseline characteristics of participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study


McNeil, JJ and Woods, RL and Nelson, MR and Murray, AM and Reid, CM and Kirpach, B and Storey, E and Shah, RC and Wolfe, RS and Tonkin, AM and Newman, AB and Williamson, JD and Lockery, JE and Margolis, KL and Ernst, ME and Abhayaratna, WP and Stocks, N and Fitzgerald, SM and Trevaks, RE and Orchard, SG and Beilin, LJ and Donnan, GA and Gibbs, P and Johnston, CI and Grimm, RH, on behalf of the ASPREE Investigator Group, Baseline characteristics of participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study, Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 72, (11) pp. 1586-1593. ISSN 1079-5006 (2017) [Refereed Article]

Copyright Statement

Copyright The Author 2017

DOI: doi:10.1093/gerona/glw342


Background: There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin in Reducing Events in the Elderly (ASPREE) is a placebo-controlled trial of low-dose aspirin that will determine whether 5 years of daily 100-mg enteric-coated aspirin extends disability-free and dementia-free life in a healthy elderly population and whether these benefits outweigh the risks.

Methods: Set in primary care, this randomized double-blind placebo-controlled trial has a composite primary endpoint of death, incident dementia or persistent physical disability. Participants aged 70+ years (non-minorities) or 65+ years (U.S. minorities) were free of cardiovascular disease, dementia, or physical disability and without a contraindication to, or indication for, aspirin. Baseline data include physical and lifestyle, personal and family medical history, hemoglobin, fasting glucose, creatinine, lipid panel, urinary albumin:creatinine ratio, cognition (3MS, HVLT-R, COWAT, SDMT), mood (CES-D-10), physical function (gait speed, grip strength), Katz activities of daily living and quality of life (SF-12).

Results: Recruitment ended in December 2014 with 16,703 Australian and 2,411 U.S. participants, a median age of 74 (range 65-98) years and 56% women. Approximately 55% of the U.S. cohort were from minority groups; 9% of the total cohort. Proportions with hypertension, overweight, and chronic kidney disease were similar to age-matched populations from both countries although lower percentages had diabetes, dyslipidemia, and osteoarthritis.

Discussion: Findings from ASPREE will be generalizable to a healthier older population in both countries and will assess whether the broad benefits of daily low-dose aspirin in prolonging independent life outweigh the risks.

Item Details

Item Type:Refereed Article
Keywords:clinical trial, dementia, disability, primary prevention
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Nelson, MR (Professor Mark Nelson)
ID Code:116206
Year Published:2017
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-05-03
Last Modified:2018-12-13

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