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Baseline characteristics of participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study
Methods: Set in primary care, this randomized double-blind placebo-controlled trial has a composite primary endpoint of death, incident dementia or persistent physical disability. Participants aged 70+ years (non-minorities) or 65+ years (U.S. minorities) were free of cardiovascular disease, dementia, or physical disability and without a contraindication to, or indication for, aspirin. Baseline data include physical and lifestyle, personal and family medical history, hemoglobin, fasting glucose, creatinine, lipid panel, urinary albumin:creatinine ratio, cognition (3MS, HVLT-R, COWAT, SDMT), mood (CES-D-10), physical function (gait speed, grip strength), Katz activities of daily living and quality of life (SF-12).
Results: Recruitment ended in December 2014 with 16,703 Australian and 2,411 U.S. participants, a median age of 74 (range 65-98) years and 56% women. Approximately 55% of the U.S. cohort were from minority groups; 9% of the total cohort. Proportions with hypertension, overweight, and chronic kidney disease were similar to age-matched populations from both countries although lower percentages had diabetes, dyslipidemia, and osteoarthritis.
Discussion: Findings from ASPREE will be generalizable to a healthier older population in both countries and will assess whether the broad benefits of daily low-dose aspirin in prolonging independent life outweigh the risks.
History
Publication title
Journals of Gerontology, Series A: Biological Sciences and Medical SciencesVolume
72Issue
11Pagination
1586-1593ISSN
1079-5006Department/School
Menzies Institute for Medical ResearchPublisher
Gerontological Society AmerPlace of publication
1275 K Street Nw Suite 350, Washington, USA, Dc, 20005-4006Rights statement
Copyright The Author 2017Repository Status
- Restricted