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Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy

Citation

Afshari, NA and Igo Jr, RP and Morris, NJ and Stambolian, D and Sharma, S and Pulagam, VL and Dunn, S and Stamler, JF and Truitt, BJ and Rimmler, J and Kuot, A and Croasdale, CR and Qin, X and Burdon, KP and Riazuddin, SA and Mills, R and Klebe, S and Minear, MA and Zhao, J and Balajonda, E and Rosenwasser, GO and Baratz, KH and Mootha, VV and Patel, SV and Gregory, SG and Bailey-Wilson, JE and Price, MO and Price, FW and Craig, JE and Fingert, JH and Gottsch, JD and Aldave, AJ and Klintworth, GK and Lass, JH and Li, YJ and Iyengar, SK, Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy, Nature Communications, 8 Article 14898. ISSN 2041-1723 (2017) [Refereed Article]


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Copyright Statement

Copyright The Author(s) 2017. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1038/ncomms14898

Abstract

The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal disorder requiring transplantation, we conducted a genome-wide association study (GWAS) on 1,404 FECD cases and 2,564 controls of European ancestry, followed by replication and meta-analysis, for a total of 2,075 cases and 3,342 controls. We identify three novel loci meeting genome-wide significance (P<5 10-8): KANK4 rs79742895, LAMC1 rs3768617 and LINC00970/ATP1B1 rs1200114. We also observe an overwhelming effect of the established TCF4 locus. Interestingly, we detect differential sex-specific association at LAMC1, with greater risk in women, and TCF4, with greater risk in men. Combining GWAS results with biological evidence we expand the knowledge of common FECD loci from one to four, and provide a deeper understanding of the underlying pathogenic basis of FECD.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Hearing, Vision, Speech and Their Disorders
Author:Burdon, KP (Associate Professor Kathryn Burdon)
ID Code:116185
Year Published:2017
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-05-03
Last Modified:2017-07-31
Downloads:9 View Download Statistics

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