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Quantifying lung shunting during planning for radio-embolization

Citation

Willowson, K and Bailey, DL and Baldock, C, Quantifying lung shunting during planning for radio-embolization, Physics in Medicine and Biology, 56, (13) pp. N145-N152. ISSN 0031-9155 (2011) [Refereed Article]

Copyright Statement

2011 Institute of Physics and Engineering in Medicine

DOI: doi:10.1088/0031-9155/56/13/N01

Abstract

A method is proposed for accurate quantification of lung uptake during shunt studies for liver cancer patients undergoing radio-embolization. The current standard for analysis of [99mTc]-MAA shunt studies is subjective and highly variable. The technique proposed in this work involves a small additional peripheral intravenous injection of macroaggregated albumin (MAA) and two additional static acquisitions (before and after injection) to quantify the absolute activity in the lungs as a result of arterio-venous shunting. Such quantification also allows for estimates of absorbed dose to lung tissue at the time of treatment based on MIRD formalism. The method was used on six radio-embolization patients attending the department for lung shunt analysis. Quantitative values for each were compared to a previously validated technique using fully quantitative SPECT/CT imaging, treated as the gold standard. The average difference between absolute activity shunted to the lungs calculated by the proposed technique compared to the previously validated technique was found to be 2%, with a range of (18)%. The proposed method is simple and fast, allowing for accurate quantification of lung shunting and estimates of absorbed dose to lung tissue at treatment, and may one day be used in a one-stop procedure for planning and therapy in a single interventional procedure.

Item Details

Item Type:Refereed Article
Keywords:absorbed dose, interventional procedures, liver cancer
Research Division:Physical Sciences
Research Group:Other Physical Sciences
Research Field:Medical Physics
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Baldock, C (Professor Clive Baldock)
ID Code:116138
Year Published:2011
Web of Science® Times Cited:7
Deposited By:Research Operations
Deposited On:2017-05-02
Last Modified:2017-11-01
Downloads:0

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