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Relevance of the T cell receptor-ligand avidity for immunity to infection


Nauerth, M and Wing, K and Korner, H and Busch, DH, Relevance of the T cell receptor-ligand avidity for immunity to infection, Journal of Microbial & Biochemical Technology, 8, (2) pp. 131-135. ISSN 1948-5948 (2016) [Contribution to Refereed Journal]


Copyright Statement

Copyright: 2016 Nauerth M, et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.4172/1948-5948.1000275


Cytotoxic lymphocytes are critical for fighting viral and certain bacterial infections. Therefore, assessing the quality of cytotoxic T cell responses might have important clinical implications. TCR-pMHC binding (avidity) is a key determinant of T cell quality. Here we review currently available technologies for the measurement of TCR-pMHC avidity and their potential relevance for translational applications.

Item Details

Item Type:Contribution to Refereed Journal
Keywords:T cell, T cell receptor, avidity, intracellular infections, immunotherapies
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:116000
Year Published:2016
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-04-27
Last Modified:2017-08-30
Downloads:137 View Download Statistics

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