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Relevance of the T cell receptor-ligand avidity for immunity to infection
Citation
Nauerth, M and Wing, K and Korner, H and Busch, DH, Relevance of the T cell receptor-ligand avidity for immunity to infection, Journal of Microbial & Biochemical Technology, 8, (2) pp. 131-135. ISSN 1948-5948 (2016) [Contribution to Refereed Journal]
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Copyright Statement
Copyright: © 2016 Nauerth M, et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.4172/1948-5948.1000275
Abstract
Cytotoxic lymphocytes are critical for fighting viral and certain bacterial infections. Therefore, assessing the quality of cytotoxic T cell responses might have important clinical implications. TCR-pMHC binding (avidity) is a key determinant of T cell quality. Here we review currently available technologies for the measurement of TCR-pMHC avidity and their potential relevance for translational applications.
Item Details
| Item Type: | Contribution to Refereed Journal |
|---|---|
| Keywords: | T cell, T cell receptor, avidity, intracellular infections, immunotherapies |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Immunology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Korner, H (Professor Heinrich Korner) |
| ID Code: | 116000 |
| Year Published: | 2016 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2017-04-27 |
| Last Modified: | 2017-08-30 |
| Downloads: | 137 View Download Statistics |
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