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Relevance of the T cell Receptor-Ligand Avidity for Immunity to Infection

Citation

Nauerth, M and Wing, K and Korner, H and Busch, DH, Relevance of the T cell Receptor-Ligand Avidity for Immunity to Infection, Journal of Microbial & Biochemical Technology, 8, (2) pp. 131-135. ISSN 1948-5948 (2016) [Refereed Article]


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Copyright Statement

Copyright: 2016 Nauerth M, et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.4172/1948-5948.1000275

Abstract

Cytotoxic lymphocytes are critical for fighting viral and certain bacterial infections. Therefore, assessing the quality of cytotoxic T cell responses might have important clinical implications. TCR-pMHC binding (avidity) is a key determinant of T cell quality. Here we review currently available technologies for the measurement of TCR-pMHC avidity and their potential relevance for translational applications.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Korner, H (Professor Heinrich Korner)
ID Code:116000
Year Published:2016
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-04-27
Last Modified:2017-06-13
Downloads:10 View Download Statistics

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