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Viana et al. 2017 JAD Ethics DBS EOAD.pdf (622.27 kB)

Ethical considerations for deep brain stimulation trials in patients with early-onset Alzheimer’s disease

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posted on 2023-05-19, 03:58 authored by Viana, JN, Bittlinger, M, Frederic GilbertFrederic Gilbert
Several studies of deep brain stimulation (DBS) of the fornix or the nucleus basalis of Meynert have been recently conducted in people with Alzheimer’s disease, with several recruiting participants <65 and thus have early-onset Alzheimer’s disease (EOAD). Although EOAD accounts for less than 5.5% of AD cases, ethical considerations must still be made when performing DBS trials including these participants since a portion of people with EOAD, especially those possessing autosomal-dominant mutations, have an atypical and more aggressive disease progression. These considerations include appropriate patient selection and signing of an informed consent for genetic testing; appropriate study design; potential outcomes that people with EOAD could expect; and accurate interpretation and balanced discussion of trial results. Finally, recommendations for future DBS for AD trials will be made to ensure that EOAD patients will not experience avoidable harms should they be enrolled in these experimental studies.

History

Publication title

Journal of Alzheimer's Disease

Volume

58

Pagination

289-301

ISSN

1387-2877

Department/School

School of Creative Arts and Media

Publisher

IOS Press

Place of publication

Netherlands

Rights statement

© 2017 – IOS Press and the authors

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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