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Physicochemical stability of voriconazole in elastomeric devices


Harmanjeet, H and Zaidi, STR and Ming, LC and Wanandy, T and Patel, RP, Physicochemical stability of voriconazole in elastomeric devices, European Journal of Hospital Pharmacy, e2 pp. e88-e92. ISSN 2047-9956 (2018) [Refereed Article]

Copyright Statement

European Association of Hospital Pharmacists (unless otherwise stated in the text of the article) 2017. All rights reserved.

DOI: doi:10.1136/ejhpharm-2016-001170


Objectives: Voriconazole is the drug of choice for invasive aspergillosis (IA), a leading cause of mortality and morbidity in immunocompromised patients. Prolong intravenous administration of voriconazole is often needed in such patients due to high incidence of oral mucositis and unreliable bioavailability of oral dosage form. Administration of voriconazole through elastomeric pump may facilitate early hospital discharge of clinically stable immunocompromised patients needing prolonged intravenous treatment. Therefore, we investigated the physicochemical stability of voriconazole in one of the commonly used elastomeric pumps at three different temperatures for various time points.

Methods: A total of 18 elastomeric pumps were prepared and 6 containing 2 mg/mL of voriconazole (3 in 0.9% sodium chloride and 3 in 5% glucose) were stored at either 4C for 96 hours, 25C for 4 hours or at 35C for 4 hours. An aliquot withdrawn immediately before storage (time 0) and at various time points was analysed for chemical stability using high-performance liquid chromatography and for physical stability using visual, pH and microscopic analyses.

Results: Voriconazole was stable for at least 96 hours, 4 hours and 4 hours at 4C, 25C and 35C, respectively, when admixed with either 0.9% sodium chloride or 5% glucose. No evidence of particle formation, colour change or pH change was observed throughout the study period.

Conclusions: These findings would allow early hospital discharge using elastomeric intravenous administration of voriconazole in patients in whom oral route of administration is not available.

Item Details

Item Type:Refereed Article
Keywords:chromatography, stability, elastomeric, out patient devices
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Harmanjeet, H (Mr Harmanjeet Harmanjeet)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
UTAS Author:Ming, LC (Dr Long Ming)
UTAS Author:Wanandy, T (Mr Troy Wanandy)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:115821
Year Published:2018 (online first 2017)
Web of Science® Times Cited:3
Deposited By:Pharmacy
Deposited On:2017-04-11
Last Modified:2018-11-01

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