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Currents of memory: recent progress, translational challenges, and ethical considerations in fornix deep brain stimulation trials for Alzheimer’s disease

Citation

Viana, JN and Vickers, JC and Cook, MJ and Gilbert, F, Currents of memory: recent progress, translational challenges, and ethical considerations in fornix deep brain stimulation trials for Alzheimer's disease, Neurobiology of Aging, 56 pp. 202-210. ISSN 0197-4580 (2017) [Refereed Article]


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DOI: doi:10.1016/j.neurobiolaging.2017.03.001

Abstract

The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzheimer's disease. In this article, we summarize clinical trials and case reports on fornix deep brain stimulation for Alzheimer's disease and review experiments on animal models evaluating the physiological or behavioral effects of this intervention. Based on information from these reports and studies, we identify potential translational challenges of this approach and determine practical and ethical considerations for clinical trials, focusing on issues regarding selection criteria, trial design, and outcome evaluation. Based on initial results suggesting greater benefit for those with milder disease stage, we find it essential that participant expectations are carefully managed to avoid treatment disenchantment and/or frustration from participants and caregivers. Finally, we urge for collaboration between centers to establish proper clinical standards and to promote better trial results comparison.

Item Details

Item Type:Refereed Article
Keywords:deep brain stimulation, fornix, Alzheimer's disease, ethics, clinical trials
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurology and Neuromuscular Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Viana, JN (Mr Noel Viana)
Author:Vickers, JC (Professor James Vickers)
Author:Gilbert, F (Dr Frederic Gilbert)
ID Code:115674
Year Published:2017
Web of Science® Times Cited:1
Deposited By:Student Retention and Success
Deposited On:2017-04-04
Last Modified:2017-11-01
Downloads:0

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