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Effect of 1-h moderate-intensity aerobic exercise on intramyocellular lipids in obese men before and after a lifestyle intervention

Citation

Ipavec-Levasseur, S and Croci, I and Choquette, S and Byrne, N and Cowin, G and O'Moore-Sullivan, TM and Prins, JB and Hickman, IJ, Effect of 1-h moderate-intensity aerobic exercise on intramyocellular lipids in obese men before and after a lifestyle intervention, Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme, 40, (12) pp. 1262-1268. ISSN 1715-5312 (2015) [Refereed Article]

DOI: doi:10.1139/apnm-2015-0258

Abstract

Intramyocellular lipids (IMCL) are depleted in response to an acute bout of exercise in lean endurance-trained individuals; however, it is unclear whether changes in IMCL content are also seen in response to acute and chronic exercise in obese individuals. We used magnetic resonance spectroscopy in 18 obese men and 5 normal-weight controls to assess IMCL content before and after an hour of cycling at the intensity corresponding with each participant's maximal whole-body rate of fat oxidation (Fatmax). Fatmax was determined via indirect calorimetry during a graded exercise test on a cycle ergometer. The same outcome measures were reassessed in the obese group after a 16-week lifestyle intervention comprising dietary calorie restriction and exercise training. At baseline, IMCL content decreased in response to 1 h of cycling at Fatmax in controls (2.8 ± 0.4 to 2.0 ± 0.3 A.U., -39%, p = 0.02), but not in obese (5.4 ± 2.1 vs. 5.2 ± 2.2 A.U., p = 0.42). The lifestyle intervention lead to weight loss (-10.0 ± 5.4 kg, p < 0.001), improvements in maximal aerobic power (+5.2 ± 3.4 mL/(kg·min)), maximal fat oxidation rate (+0.19 ± 0.22 g/min), and a 29% decrease in homeostasis model assessment score (all p < 0.05). However, when the 1 h of cycling at Fatmax was repeated after the lifestyle intervention, there remained no observable change in IMCL (4.6 ± 1.8 vs. 4.6 ± 1.9 A.U., p = 0.92). In summary, there was no IMCL depletion in response to 1 h of cycling at moderate intensity either before or after the lifestyle intervention in obese men. An effective lifestyle intervention including moderate-intensity exercise training did not impact rate of utilisation of IMCL during acute exercise in obese men.

Item Details

Item Type:Refereed Article
Keywords:diet; diète; ectopic fat; energy metabolism; entraînement physique; exercise training; graisse ectopique; intramyocellular triglycerides; magnetic resonance spectroscopy; maximal fat oxidation; muscle; métabolisme énergétique; obesity; obésité; oxyda
Research Division:Medical and Health Sciences
Research Group:Human Movement and Sports Science
Research Field:Exercise Physiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Byrne, N (Professor Nuala Byrne)
ID Code:115661
Year Published:2015
Web of Science® Times Cited:3
Deposited By:Health Sciences
Deposited On:2017-04-04
Last Modified:2017-10-31
Downloads:0

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